Cardioprotective effect of Cinnamomum zeylanicum extract on rats fed on high fat high fructose diet | ||
| Bulletin of Egyptian Society for Physiological Sciences | ||
| Volume 42, Issue 4, October 2022, Pages 344-358 PDF (457.92 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/besps.2022.135210.1123 | ||
| Authors | ||
| Noura fathy Elmongy* 1; Ismail A Hussein2; Walid mostafa said ahmed3; Ibrahim M Shatla3 | ||
| 1Department of Physiology, Damietta Faculty of Medicine, Al-Azhar University, Damietta, Egypt | ||
| 2Department of Pharmacognosy and Medicinal Plants, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo 11884, Egypt; | ||
| 3Department of Physiology, Damietta Faculty of Medicine, Al-Azhar University, Damietta, Egypt. | ||
| Abstract | ||
| Background: As a result of the increased consumption of sugar-rich and fatty-products, and the increase in the preference for such products, metabolic disorders are becoming more common at a younger age. Hyperlipidemia, insulin resistance [IR] and inflammatory status induced by high fat high fructose diet [HFHFD] increase the risk of developing cardiovascular diseases [CVDs] which are the leading cause of death worldwide. Objective: This study is aiming to determine the effects of HFHFD on cardiovascular disease [CVD]-related parameters. Also, the possible protective and curative effects of cinnamon extract on cardiac diseases. Methodology: Fifty adult male Sprague Dawley rats were divided into five groups: Group I: [control]. Group II rats were fed a diet with 45 kcal% fat and drink fructose 60% [HFHFD] for 8w. Group III: fed on HFHFD and pioglitazone [PGZ 20 mg/kg/b.wt]. Group IV: fed on HFHFD and cinnamon extract200mg/kg.b.w. Group V: fed on HFHFD and treated with combination of PGZ drug and cinnamon extract. Results: HFHFD administration resulted signs of cardiomyopathy revealed by significant increase in blood glucose, serum insulin, homeostasis model assessment of IR [HOMA- IR] index with disturbed lipid profile. Also, significant increase in serum cardiac enzymes, inflammatory cytokines and oxidative stress markers were also noticed. PGZ and cinnamon extract treatment resulted in a significant decrease in glucose, insulin, and HOMA- IR index, amelioration of lipid profile, cardiac enzymes, inflammatory cytokines and oxidative stress markers | ||
| Keywords | ||
| Insulin resistance; Cardiomyopathy; Cinnamon; High fat high fructose diet; Pioglitazone | ||
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