Serum Level of Wingless Integration 5a Protein in Rheumatoid Arthritis | ||||
| The Egyptian Journal of Hospital Medicine | ||||
| Article 216, Volume 89, Issue 1, October 2022, Page 5501-5504 PDF (457.66 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ejhm.2022.264849 | ||||
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| Authors | ||||
Asmaa E. Yaseen  ; Mohammad H. El-Gawish; Ibrahim T. AbdElal; Eman S. Algharabawy
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| Abstract | ||||
| Background: Genesis and molecular etiology of rheumatoid arthritis (RA) remain important in spite novel achievements of disease modifying anti-rheumatic drugs (DMARDs). Wnt5a is up regulated in synovial fibroblasts among RA patients, suggesting it could contribute to the development of illness. Objective: To measure Wnt5a protein levels among RA patients’ serum and to find its relationship with disease activity. Patients and Methods: Twenty patients with RA and twenty people without the disease who were matched for age and sex served as the study's control group. The patients were all examined thoroughly and had taken their histories. The Disease Activity Score-28 was used to measure disease severity (DAS-28). All participants gave their serum Wnt5a levels assessed using an enzyme-linked immunosorbent test (ELISA). Patients’ complete blood cell count, anti-cyclic citrullinated peptide (anti-CCP) titer, rheumatoid factor titer, C-reactive protein, as well as erythrocyte sedimentation rate were determined. Results: Serum Wnt5a levels of RA patients were significantly higher than those of the control group. Wnt5a levels correlated positively with several other measures of inflammation and illness severity (DAS-28, ESR, CRP, RF, and disease duration). Serum Wnt5a was not correlated with age, sex, or Anti-CCP. With an area under the curve of 0.891, a specificity of 75%, a sensitivity of 80%, NPV of 65.2%, PPV of 86.5% and an accuracy of 78.3%, a cutoff of being equal or higher than 2.06 ng/ml for serum Wnt5a protein in the diagnosis of RA was optimal. Conclusion: Results from the current investigation revealed a correlation between Wnt5a and RA. | ||||
| Keywords | ||||
| Wnt5a; Rheumatoid arthritis; Disease activity | ||||
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