Crosstalk between Maternal Life and Fetal Epigenome; A Review Article | ||
| Journal of Advanced Pharmacy Research | ||
| Article 2, Volume 6, Issue 4, October 2022, Pages 181-191 PDF (584.83 K) | ||
| Document Type: Review Article | ||
| DOI: 10.21608/aprh.2022.144865.1181 | ||
| Authors | ||
| Shahenda Mahgoub1; Hadeer Abosalem2; Dina Mahmoud2; Doaa Abdel Mohsen* 1; Zeinab Abd-eltwab1 | ||
| 1Department of Biochemistry and Molecular Biology, Faculty of Pharmacy, Helwan University, Ein-Helwan, Helwan, Cairo,11795, Egypt. | ||
| 2Egyptian drug authority (EDA), Giza, 12654, Egypt. | ||
| Abstract | ||
| Background: It is important to say that maternal lifestyle during gestation could affect embryonic development and health consequences. Objectives: Many endogenous and exogenous factors affect the epigenetics of the germ cells during their division and subsequently affect the embryogenesis. Methods: This systematic review outline various studies that link the different environmental factors and modification in the fetal epigenome. Conclusion: Aberrant fetal epigenome modification subsequently affects the healthy embryonic growth and their contribution to the phenotypic changes and chronic disease development later in life. | ||
| Keywords | ||
| Epigenetic modifications; Covid; Histone remodeling; Prenatal health; Radiation | ||
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