Protective Effect of Taurine Against Bisphenol A -Induced Hepatotoxicity in Albino Rats | ||
| The Egyptian Journal of Hospital Medicine | ||
| Article 28, Volume 89, Issue 2, October 2022, Pages 6226-6230 PDF (862.44 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/ejhm.2022.268121 | ||
| Authors | ||
| Esam Mohamed Abd- Allah; Maha Abd El Hameed Hilal; Doha Saber Mohamed; Azza Omar Hassan; Ahmed Mohamed Said | ||
| Abstract | ||
| Background: Bisphenol A (BPA) is one of the most utilized industrial chemicals worldwide. It is commonly found in a variety of consumer products. Taurine is a natural product; has been shown to protect cells against the cytotoxic effects and inflammations associated with oxidative stress and provide anti-inflammatory effects. Objectives: This study was designed to investigate the toxic effects of BPA on the liver and evaluate the possible protective effect of taurine. Methods: Forty adult male albino rats were divided equally into four groups (10 rats per group). Group I: Rats fed on basal diet and distilled water. Group II: Received taurine orally (100 mg /kg /day). Group III: Rats treated orally with bisphenol (130 mg /kg /day). Group IV received BPA and taurine. After one month, all animals were sacrificed and blood was collected for analysis. Results: There is increased serum AST& ALT level and histopathological changes in liver. Toxic effects declined markedly with taurine co-administration. Conclusions: The present study concluded that BPA has many toxic effects on liver, taurine has a potential protective effect against such harmful effects. | ||
| Keywords | ||
| BPA; Taurine; Alanine transaminase (ALT); Aspartate transaminase (AST); liver | ||
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