Cathepsin L is A Potential Marker for Triple-Negative Breast Cancer
El-Nadi, M., Hassan, H., Amer, M., Mohamed, M., El-Shinawi, M., Ibrahim, S. (2019). Cathepsin L is A Potential Marker for Triple-Negative Breast Cancer. EKB Journal Management System, 11(1), 29-36. doi: 10.21608/eajbsc.2019.26817
Mennatullah El-Nadi; Hebatallah Hassan; Mahmoud Amer; Mona Mostafa Mohamed; Mohamed El-Shinawi; Sherif Abdelaziz Ibrahim. "Cathepsin L is A Potential Marker for Triple-Negative Breast Cancer". EKB Journal Management System, 11, 1, 2019, 29-36. doi: 10.21608/eajbsc.2019.26817
El-Nadi, M., Hassan, H., Amer, M., Mohamed, M., El-Shinawi, M., Ibrahim, S. (2019). 'Cathepsin L is A Potential Marker for Triple-Negative Breast Cancer', EKB Journal Management System, 11(1), pp. 29-36. doi: 10.21608/eajbsc.2019.26817
El-Nadi, M., Hassan, H., Amer, M., Mohamed, M., El-Shinawi, M., Ibrahim, S. Cathepsin L is A Potential Marker for Triple-Negative Breast Cancer. EKB Journal Management System, 2019; 11(1): 29-36. doi: 10.21608/eajbsc.2019.26817

Cathepsin L is A Potential Marker for Triple-Negative Breast Cancer

Egyptian Academic Journal of Biological Sciences. C, Physiology and Molecular Biology
Article 3, Volume 11, Issue 1, June 2019, Pages 29-36    PDF (708.11 K)
Document Type: Original Article
DOI: 10.21608/eajbsc.2019.26817
Authors
Mennatullah El-Nadi1; Hebatallah Hassan1; Mahmoud Amer1; Mona Mostafa Mohamed1; Mohamed El-Shinawi2; Sherif Abdelaziz Ibrahim1
1Department of Zoology, Faculty of Science, Cairo University, Cairo University, Giza, 12613, Egypt
2Department of General Surgery, Faculty of Medicine, Ain Shams University, Cairo, 11566, Egypt
Abstract
Breast cancer is the second cancer-related death among women worldwide. Triple-negative breast cancer (TNBC) is the most aggressive and lethal subtype, which is associated with high metastasis and poor prognosis. Cathepsins, a family of lysosomal cysteine proteases, such as cathepsin L (CTSL), are involved in cancer invasion and metastasis. Thus, CTSL may emerge as a marker for TNBC. So, we characterized the expression of CTSL mRNA in tissue specimen of TNBC (n = 10) and non-TNBC (non-TN) (n = 10) using quantitative real-time PCR. Data were statistically analyzed using Mann-Whitney U-test. Our data demonstrate that CTSL mRNA expression was up-regulated in TN BC vs. non-TN BC patients. In conclusion, the high expression of CTSL may represent a marker for TNBC and its targeting could have therapeutic implications
Keywords
Triple-negative; breast cancer; Cathepsin L
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