Cathepsin L is A Potential Marker for Triple-Negative Breast Cancer | ||||
Egyptian Academic Journal of Biological Sciences. C, Physiology and Molecular Biology | ||||
Article 3, Volume 11, Issue 1, June 2019, Page 29-36 PDF (708.11 K) | ||||
Document Type: Original Article | ||||
DOI: 10.21608/eajbsc.2019.26817 | ||||
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Authors | ||||
Mennatullah El-Nadi1; Hebatallah Hassan1; Mahmoud Amer1; Mona Mostafa Mohamed1; Mohamed El-Shinawi2; Sherif Abdelaziz Ibrahim1 | ||||
1Department of Zoology, Faculty of Science, Cairo University, Cairo University, Giza, 12613, Egypt | ||||
2Department of General Surgery, Faculty of Medicine, Ain Shams University, Cairo, 11566, Egypt | ||||
Abstract | ||||
Breast cancer is the second cancer-related death among women worldwide. Triple-negative breast cancer (TNBC) is the most aggressive and lethal subtype, which is associated with high metastasis and poor prognosis. Cathepsins, a family of lysosomal cysteine proteases, such as cathepsin L (CTSL), are involved in cancer invasion and metastasis. Thus, CTSL may emerge as a marker for TNBC. So, we characterized the expression of CTSL mRNA in tissue specimen of TNBC (n = 10) and non-TNBC (non-TN) (n = 10) using quantitative real-time PCR. Data were statistically analyzed using Mann-Whitney U-test. Our data demonstrate that CTSL mRNA expression was up-regulated in TN BC vs. non-TN BC patients. In conclusion, the high expression of CTSL may represent a marker for TNBC and its targeting could have therapeutic implications | ||||
Keywords | ||||
Triple-negative; breast cancer; Cathepsin L | ||||
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