Role of interleukin-17 and interleukin 23R gene polymorphism and serum interleukin 17A in rheumatoid arthritis
Ahmed, H., Fattouh, M., Ismail, M., Goda, A. (2023). Role of interleukin-17 and interleukin 23R gene polymorphism and serum interleukin 17A in rheumatoid arthritis. EKB Journal Management System, 27(1.), 1-9. doi: 10.21608/smj.2022.168633.1348
Hala abdelaal Ahmed; Mona fattouh Fattouh; Mohammed Ismail; Asmaa mohamed Goda. "Role of interleukin-17 and interleukin 23R gene polymorphism and serum interleukin 17A in rheumatoid arthritis". EKB Journal Management System, 27, 1., 2023, 1-9. doi: 10.21608/smj.2022.168633.1348
Ahmed, H., Fattouh, M., Ismail, M., Goda, A. (2023). 'Role of interleukin-17 and interleukin 23R gene polymorphism and serum interleukin 17A in rheumatoid arthritis', EKB Journal Management System, 27(1.), pp. 1-9. doi: 10.21608/smj.2022.168633.1348
Ahmed, H., Fattouh, M., Ismail, M., Goda, A. Role of interleukin-17 and interleukin 23R gene polymorphism and serum interleukin 17A in rheumatoid arthritis. EKB Journal Management System, 2023; 27(1.): 1-9. doi: 10.21608/smj.2022.168633.1348

Role of interleukin-17 and interleukin 23R gene polymorphism and serum interleukin 17A in rheumatoid arthritis

Sohag Medical Journal
Volume 27, Issue 1., 2023, Page 1-9  XML PDF (549.36 K)
Document Type: Original Article
DOI: 10.21608/smj.2022.168633.1348
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Authors
Hala abdelaal Ahmed email 1; Mona fattouh Fattouh2; Mohammed Ismail3; Asmaa mohamed Goda4
1assistant lecturer of medical microbiology and immunology faculty of medicine
2Department of Medical Microbiology and Immunology, Sohag Faculty of Medicine, Sohag University
3Assistant professor of rheumatology and rehabilitation Sohag University
4Assistant professor of medical microbiology and immunology Sohag University
Abstract
The multistep process of rheumatoid arthritis (RA), a chronic autoimmune disease, includes the interaction of genetic, environmental, and behavioural risk factors that break immune tolerance and trigger autoimmune processes like the production of autoantibodies, the emergence of the first symptoms prior to the development of clinical arthritis, and finally the appearance of arthritis. In rheumatoid arthritis, the interleukin (IL)-17/IL-23 axis is a crucial pro-inflammatory mechanism (RA). IL-17 is the important factor of inflammation and is contribute to the destruction of bone by increasing the migration of cells, the gene expression of chemokines and the invasiveness of synoviocytes. There are a number of variations in the IL17A gene, and these polymorphisms may affect how IL-17 is expressed. The Th17 has been shown to be more effective than other cells in the development of autoimmune illness. In psoriasis and inflammatory bowel disease patients, IL-23 receptor gene variations were found to raise susceptibilities to autoimmune illness. Investigations also revealed that synovial fibroblasts and plasma from RA patients expressed more IL-23 than normal. Therefore, RA risk may be associated with IL-23 receptor gene variation.
Keywords
rheumatoid arthritis; IL-17A; IL-23R
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