1-Preparation, Characterization, and Efficiency of Loading Leiurus quinquestriatus Venom on Chitosan Nanoparticles Extracted from Some Scorpions . | ||
| Egyptian Academic Journal of Biological Sciences, B. Zoology | ||
| Volume 14, Issue 2, December 2022, Pages 373-396 PDF (3.5 M) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/eajbsz.2022.272455 | ||
| Authors | ||
| Mostafa A. El-Sheikh; Ahmed Badry; Mohamed Abdelaal; Ahmed Abd El-Aziz | ||
| Zoology Department, Faculty of Science, Al-Azhar University, Cairo, Egypt | ||
| Abstract | ||
| Aim: This investigation aims to extract chitin and chitosan from the three scorpions: Leiurus quinquestriatus (LQ), Androctonus crassicauda (AC) and Androctonus amoreuxi (AA) for the first time and to determine the loading capacity and efficiency of LQ venom-loaded chitosan nanoparticles (V-CN). Methods: chitin was extracted and converted to chitosan which is converted to nanoparticles (Cs-NPs) by ball-milling technique. LQ venom was collected, characterized, and loaded on Cs-NPs via the ionic gelation method. Different techniques were used to characterize the obtained compounds. Results: the dried powder of LQ, AC, and AA contained 19.7 %, 15.4 %, and 15 % chitin, respectively. FT-IR confirmed the successful preparation of chitin, chitosan, and V-CN samples. Loading capacity reached 76.50 %, while encapsulation efficiency reached 87.98 %. Conclusion: scorpion venom was effectively loaded on chitosan samples. Its physical and compound qualities, specifically, were viewed as great for biomedical and drug applications. | ||
| Keywords | ||
| Scorpion venom; chitosan; chitosan nanoparticles; ionic gelation | ||
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