Rosemary and hesperidin alleviate cardiac dysfunction and alter cellular signaling pathways in experimental model of diabetic cardiomyopathy
Hussein, S., Abo zaid, O., Abdelmaksoud, H., Ismael, T., Al lawaty, G. (2022). Rosemary and hesperidin alleviate cardiac dysfunction and alter cellular signaling pathways in experimental model of diabetic cardiomyopathy. EKB Journal Management System, 42(2), 37-42. doi: 10.21608/bvmj.2022.148132.1545
Samy Ali Hussein; omayma ragab Abo zaid; Hussein Abdelmaksoud; Taheya Ismael; Ghada Fathy Al lawaty. "Rosemary and hesperidin alleviate cardiac dysfunction and alter cellular signaling pathways in experimental model of diabetic cardiomyopathy". EKB Journal Management System, 42, 2, 2022, 37-42. doi: 10.21608/bvmj.2022.148132.1545
Hussein, S., Abo zaid, O., Abdelmaksoud, H., Ismael, T., Al lawaty, G. (2022). 'Rosemary and hesperidin alleviate cardiac dysfunction and alter cellular signaling pathways in experimental model of diabetic cardiomyopathy', EKB Journal Management System, 42(2), pp. 37-42. doi: 10.21608/bvmj.2022.148132.1545
Hussein, S., Abo zaid, O., Abdelmaksoud, H., Ismael, T., Al lawaty, G. Rosemary and hesperidin alleviate cardiac dysfunction and alter cellular signaling pathways in experimental model of diabetic cardiomyopathy. EKB Journal Management System, 2022; 42(2): 37-42. doi: 10.21608/bvmj.2022.148132.1545

Rosemary and hesperidin alleviate cardiac dysfunction and alter cellular signaling pathways in experimental model of diabetic cardiomyopathy

Benha Veterinary Medical Journal
Volume 42, Issue 2, September 2022, Pages 37-42    PDF (1.2 M)
Document Type: Original Article
DOI: 10.21608/bvmj.2022.148132.1545
Authors
Samy Ali Hussein1; omayma ragab Abo zaid2; Hussein Abdelmaksoud3; Taheya Ismael4; Ghada Fathy Al lawaty* 3
1Department of Biochemistry, Faculty of Vet. Med., Benha University, Egypt.
2Biochemistry veterinary medicine Banha university
3Biochemistry- veterinary medicine- benha University-Egypt
4Nutrition &Clinical Nutrition- veterinary medicine- benha University-Egypt
Abstract
Alterations in the cardiac structure and function are the hallmarks of diabetic cardiomyopathy (DCM), separate coronary heart disease in diabetic patients. In a streptozotocin-induced diabetic rat model, the current research aimed to investigate the preventive effects of rosemary extract and hesperidin on DCM. Fifty male Rats were divided into five main groups. Group Ι: rats received no drugs. Group Π: STZ (50 mg/kg b. wt.) was given intraperitoneally (i.p.) to rats just once. Group III: Rats treated with insulin at a dose of (2 U/rat/day). Group IV: rats treated with Rosemary extract at a dose of (200 mg/kg b. wt /day). Group V: rats treated with Hesperidin at a dose of (100 mg/kg b. wt/day). The results showed a marked increase in serum total cholesterol and triacylglycerol concentrations and downregulation in Peroxisome proliferator-activated receptor-γ (PPAR-γ) and Sarcoplasmic reticulum Ca2+-ATPase (SERCA) genes expressions with upregulation in Collagen type IV (COL4) in cardiac tissue of DCM-induced group. Treatment with insulin, rosemary extract, or hesperidin to STZ-induced DCM in rats exhibited a substantial reduction in the levels of triacylglycerol and total cholesterol with an enormous downregulation of COL4 gene expression level in cardiac tissue. However, PPAR-γ and SERCA genes exhibited an enormous upregulation. In conclusion, the results indicated that rosemary extract and hesperidin have a beneficial effect in preventing lipid metabolic disorders and diabetes complications and modify several genes such as PPAR-γ, SERCA, and COL4 participating in cellular pathways which altered in DCM.
Keywords
Diabetic cardiomyopathy; rosemary extract; hesperidin; SERCA and PPAR-γ
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