Evaluation Of Systemic Omega-3 PUFAs On Orthodontic Tooth Movement In A Rabbit Model: Randomized Clinical Trial | ||
| Egyptian Orthodontic Journal | ||
| Article 11, Volume 62, Issue 1, December 2022, Pages 117-128 PDF (345.24 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/eos.2022.172634.1056 | ||
| Authors | ||
| Asser M Gad* 1; Samia O Soliman2 | ||
| 1Lecturer of orthodontics, Faculty of dentistry, KafrelSheikh univeristy | ||
| 2Biology department, Faculty of dentistry, Alexandria University | ||
| Abstract | ||
| Objective: is to evaluate the effect of systemic administration of Omega-3 fatty acids on orthodontic tooth movement (OTM) with histological analysis. Materials and Methods: OTM was induced in 20 adult albino New Zealand rabbits with NiTi coil spring for 21 days. Omega-3 or Saline was given every day via oral gavage during experimental period. Animals were sacrificed for histomorphometric analysis of alveolar bone remodeling after 21 days of OTM. Results: A significant difference in OTM amount was found in the 3rd week of OTM with means (1.445 ± 0.13), (1.72 ± 0.15) for experimental and control groups, respectively. Histomorphometric analysis showed a significant reduction in the area of active bone-resorptive lacunae and a significant decrease in osteoclastic activity related to omega-3 group after 3 weeks. A significant difference in osteoclast count is found, omega-3 group about (0.21 ± 0.09) while control group about (0.33 ± 0.11). Conclusions: A strong evidence of the osteoclastic inhibitory effect of systemic Omega-3 had been found which decreased percentage and amount of OTM. | ||
| Keywords | ||
| Omega-3; oral gavage; OTM | ||
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