The effects of hydrogen cyanamide (dormex) on the brain and lungs of albino rats and the potential protective impact of vitamin E
Mahmoud, E., sarhan, M., Abdel Zaher, A., Refaie, M., Mohamed, O., Taghian, A. (2022). The effects of hydrogen cyanamide (dormex) on the brain and lungs of albino rats and the potential protective impact of vitamin E. EKB Journal Management System, 22(4), 85-98. doi: 10.21608/ejfsat.2022.151090.1261
Eman Shaaban Mahmoud; mohammed baker sarhan; Azza Abdel Zaher; Marwa Refaie; Omima Mohamed; Asmaa Taghian. "The effects of hydrogen cyanamide (dormex) on the brain and lungs of albino rats and the potential protective impact of vitamin E". EKB Journal Management System, 22, 4, 2022, 85-98. doi: 10.21608/ejfsat.2022.151090.1261
Mahmoud, E., sarhan, M., Abdel Zaher, A., Refaie, M., Mohamed, O., Taghian, A. (2022). 'The effects of hydrogen cyanamide (dormex) on the brain and lungs of albino rats and the potential protective impact of vitamin E', EKB Journal Management System, 22(4), pp. 85-98. doi: 10.21608/ejfsat.2022.151090.1261
Mahmoud, E., sarhan, M., Abdel Zaher, A., Refaie, M., Mohamed, O., Taghian, A. The effects of hydrogen cyanamide (dormex) on the brain and lungs of albino rats and the potential protective impact of vitamin E. EKB Journal Management System, 2022; 22(4): 85-98. doi: 10.21608/ejfsat.2022.151090.1261

The effects of hydrogen cyanamide (dormex) on the brain and lungs of albino rats and the potential protective impact of vitamin E

The Egyptian Journal of Forensic Sciences and Applied Toxicology
Volume 22, Issue 4, December 2022, Page 85-98  XML PDF (1.46 MB)
Document Type: Original Article
DOI: 10.21608/ejfsat.2022.151090.1261
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Authors
Eman Shaaban Mahmoud email 1; mohammed baker sarhanorcid 2; Azza Abdel Zaher3; Marwa Refaie4; Omima Mohamed5; Asmaa Taghian6
1department of forensic medicine and clinical toxicology, faculty of medicine, minia university, Minia city, Egypt
2egypt,minia
3department of pathology, faculty of medicine, Minia university
4department of pharmacology, faculty of medicine, Minia university, Minia, Egypt
5department of clinical pathology, faculty of medicine, Minia university, Minia, Egypt
6department of forensic medicine and clinical toxicology, faculty of medicine, Minia university, Minia, Egypt
Abstract
Objectives: Hydrogen cyanamide is the active gradient of dormex, which is sprayed on grapes for early bud break. The aim of the work: This study aims to detect the toxic effect of dormex on the brain and lungs of albino rats and the protective role of vitamin E. Methodology: This experimental study was conducted on forty-eight albino rats. They were divided randomly into four groups, with 12 rats in each group. Group I (control group) received saline. Group II received tocopherol (2 mg/kg). Group III received dormex (4 ml/kg). Group IV was given 4 mL/kg dormex and 2 mg/kg tocopherol. After 12 hours, venous blood samples were drawn for total antioxidant capacity (TAC), and then all rats were sacrificed for histopathological studies, malondialdehyde (MDA) and catalase. Dormex caused a significant increase in brain and lung MDA (0.001**), a significant decrease in brain and lung catalase (0.001**), and a significant decrease in serum total antioxidant capacity (0.001**). Vitamin E + dormex significantly reduced MDA in the brain and lungs (0.001**), significantly increased catalase in the brain and lungs (0.001**), and significantly increased serum total antioxidant capacity (0.001**). Histopathological examination of the brain and lungs in the dormex group showed marked inflammatory changes, but in the group of dormex + vitamin E, mild inflammatory changes were detected. Conclusion: The present study concluded that dormex has highly toxic effects on the brain and lungs of rats, and vitamin E could prevent these dangerous effects.
Keywords
Hydrogen Cyanamid; dormex; Malondialdehyde; catalase; total antioxidant capacity; vitamin E
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