Serum fetuin-A as a perdictive biomarker of chronic kidney disease | ||
| Aswan University Medical Journal | ||
| Volume 2, Issue 2, December 2022, Pages 97-111 PDF (940.72 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/aumj.2022.147302.1013 | ||
| Authors | ||
| Abd allah mahmoud1; Hala Mahmoud2; Atef Abo El-Fadl3; Mohammad Ali Kandeel* 4 | ||
| 1Aswan university | ||
| 2Aswan University hospital | ||
| 3Assuit University, Faculty of Medicine | ||
| 4Student Hospital, Menofia University, Shebeen El-Kom, Menofia, Egypt. | ||
| Abstract | ||
| Background: Chronic kidney disease (CKD) is a worldwide public health problem. Fetuin A is a natural calcium antagonist. Both human and animal studies have shown that low circulating fetuin A level are associated with vascular calcification and may be an independent risk factor for premature death in CKD patients. Objective: The aim of this study was to evaluate the effect of serum fetuin-A in the pathogenesis of chronic kidney disease and its correlation with routine renal biomarkers. Patients and methods: The study population was divided into 3 groups. Group I: Pre-dialysis group: on conservative treatment. Group II (CKD): on regular hemodialysis, 3 sessions/week for more than 9 months. Group III (Control group). Results: There was significant negative correlation between blood urea, serum creatinine versus serum fetuin-A in conservative group with arterial stiffness. There was significant positive correlation between eGFR and serum fetuin-A in conservative group with arterial stiffness, while there was no significant correlation between serum fetuin-A and Hb, HcT, platelets, WBCS, FBS, Na+, K+, PO4-2, serum uric acid, total bilirubin, ALT, AST, ALP, serum albumin and prothrombin time. There was significant negative correlation between serum Ca+2 and serum fetuin-A. There was significant negative correlation between total cholesterol as well as triglycerides versus serum fetuin A. Conclusion: serum fetuin-A level significantly reduced in hemodialysis patients, significantly correlated with the disease duration, and negatively correlated with serum Ca, T. cholesterol, and T.G. | ||
| Keywords | ||
| Fetuin-A; chronic kidney disease; natural calcium antagonist; hemodialysis | ||
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