T helper 17 cells and interleukin-17 contribute to the pathogenesis of primary immune thrombocytopenia in Egyptian children: a single center experience. | ||
| Zagazig University Medical Journal | ||
| Article 18, Volume 29, Issue 1, January 2023, Pages 149-154 PDF (455.87 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/zumj.2022.180391.2700 | ||
| Authors | ||
| Tamer Hassan1; Nermin Raafat Abdel-Fattah2; Asmaa Esh3; Mustafa Ismail Abu Hashim* 4 | ||
| 1pediatric department , faculty of medicine , zagazig university | ||
| 2Medical Biochemistry, Faculty of Medicine, Zagazig University, Egypt | ||
| 3Clinical pathology department,faculty of medicine,Zagazig university,Zagazig,Eygpt | ||
| 4Pediatric department, faculty of medicine, Zagazig university | ||
| Abstract | ||
| background Although the exact pathogenesis of primary immune thrombocytopenia (ITP) is still unclear, there are many research efforts directed toward the role of T helper 17 and interleukin 17 (IL -17) in the pathogenesis of this disease. The Th17 cell, which produces IL -17, is a subset of T helper cells. Interleukin 17 is a proinflammatory cytokine that has recently been shown to play a critical role in the development of autoimmune diseases. Our aim was to investigate the role of T helper cells 17 and interleukin-17 in the development of ITP in Egyptian children. Methods and results This study was performed on 100 children with ITP and 100 healthy children as a control group. Patients underwent a complete history, a thorough physical examination, and routine investigations according to our local standards. The percentage of Th17 cells was measured in the study groups by flow cytometry. Serum IL -17 was also measured by ELISA in the study groups. Th17 cells were significantly higher in patients compared with controls. In addition, serum levels of IL -17 were observed to be 3.1-fold higher in patients with ITP compared to controls. Newly diagnosed patients had a significantly higher percentage of Th-17 cells as well as higher IL -17 levels than patients with persistent or chronic ITP. conclusion We concluded that Th-17 cells and IL -17 contribute to the pathogenesis of ITP in Egyptian children. | ||
| Keywords | ||
| ITP: T helper 17; IL-17; Children; Pathogenesis | ||
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