Phytochemical Composition and Anti-SARS-CoV-2 Activity of Leaves Methanolic Extract of Silybum marianum. | ||||
| Egyptian Journal of Chemistry | ||||
| Volume 66, Issue 9, September 2023, Page 473-478 PDF (940.67 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ejchem.2022.176808.7239 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
Rasha Abdel Elatif1; Reham ElSharawy 2; Ragaa Ali Mansour3; mohamed Amin El Ansari4; Manal Hassan Shabana5; Mahmed sharaf  3
| ||||
| 1Phytochemistry and Plant Systematics Department, National Research Centre, El-Dokki, Cairo Egypt. | ||||
| 2Department of Phytochemistry and Plant Systematics, Pharmaceutical and Drug Industries Research institute, National research center, Cairo, Egypt | ||||
| 3National Research center, DOKKI, Cairo, Egypt. | ||||
| 4national research center | ||||
| 5phytochemistry and plant systematic departement,National Research Centre | ||||
| Abstract | ||||
| In line with the global interest and demand in finding sustainable ways to counteract the emerging viral pandemics, our study highlights the unique composition and anti- SARS-CoV-2 activity of a barely used and studied part of the famous medicinal plant Silybum marianum (L.) Gaertn. Various chromatographic and spectroscopic techniques used in the process of isolation and structure elucidation led to the identification of nine flavonoids for the first time from the methanolic leaves extract. Among them, the aglycone acacetin (2) was isolated for the first time from the genus. The antiviral activity of the extract against SARS-CoV-2 main protease showed considerable activity with half-maximal inhibitory and cytotoxic concentrations; IC50=80.5 µg/ml and CC50=576.5 µg/ml, respectively indicating a relatively high selectivity; SI = 7.1. | ||||
| Keywords | ||||
| Silybum marianum; Asteracea; medicinal plant; leaves; flavonoids; anti-viral activity | ||||
|
Statistics Article View: 345 PDF Download: 240 |
||||
