Interleukin-37 Expression in Primary Immune Thrombocytopenia in Egyptian Patients | ||
| Benha Medical Journal | ||
| Article 3, Volume 40, Issue 3, November and December 2023, Pages 631-639 PDF (458.99 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/bmfj.2022.170800.1694 | ||
| Authors | ||
| Fetnat Mahmoud Tolba1; amira Mohamed Noureldin Abdelrahman2; Enas Ibrahim Badr* 3; Ola Samir El-Shimi4 | ||
| 1Department of clinical & chemical pathology ., Faculty of Medicine, Benha university , Egypt | ||
| 2Department of Clinical and chemical pathology Faculty of Medicine, Benha University | ||
| 3M.B.B.Ch., Benha University, Egypt, Resident at Benha Fever Hospital. | ||
| 4Department of Clinical and Chemical Pathology, Faculty of Medicine, Benha University, Egypt. | ||
| Abstract | ||
| Background: Immune thrombocytopenia (ITP) is a bleeding disorder mediated by the immune system in which anti-platelet antibodies prematurely destroy platelets, resulting in a decreased platelet count. One of the IL-1 cytokines; IL-37, has an effect against inflammation in cancer, inflammatory and autoimmune diseases by regulating both innate and acquired immunity. Aim: Here, we evaluated the IL-37 gene both serum levels and gene expression in ITP children patients and correlated it with the disease severity. Patients & Methods: Forty newly diagnosed ITP patients and forty healthy, age- and sex-matched controls participated in a case-control study. Blood IL-37 gene mRNA expression and serum IL-37 level were both identified using ELISA and RT-qPCR, respectively. Results: ITP patients had significantly elevated serum IL-37 (P= 0.006) and IL-37 gene expression (P= 0.001) than controls. Positive correlations were found between the severity of ITP and a significantly lower platelet count, as well as significantly lower serum and gene expression levels of IL-37. Conclusion: IL-37 mRNA and serum expressions are promising biomarkers for ITP diagnosis and predictors for disease severity | ||
| Keywords | ||
| ITP; thrombocytopenia; IL-37; expression; biomarker | ||
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