New Glycosylated Flavone and Anthraquinone from Cassia notabilis Randell.: Antidiabetic, Anti-inflammatory and Analgesic Activity Evaluation | ||
| Egyptian Journal of Chemistry | ||
| Article 41, Volume 66, Issue 6, June 2023, Pages 411-418 PDF (652.32 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/ejchem.2022.178935.7271 | ||
| Authors | ||
| Mahmoud Ibrahim Nassar* 1; Rehab Fikry2; Sayed Abdel Hamid El-Toumy3; Seham Salah Eldin El Hawary4; Rania Ahmed5; Ezzel-Din El-Khrisy6 | ||
| 1Natural product chemistry, pharmaceutical institute, NRC. | ||
| 2Natural Compounds Chemistry Department, National Research Centre, Dokki, Giza, Egypt | ||
| 3Chemistry of Tannins Department, National Research Centre | ||
| 4Pharmacognosy Department, Faculty of Pharmacy, Cairo University | ||
| 5Pharmacology Department, National Research Centre | ||
| 6Natural Compounds Chemistry, National Research Centre | ||
| Abstract | ||
| The phytochemical investigation of the leaves of Cassia notabilis Randell. revealed the isolation of two new glycosides, identified as 6-methoxyapigenin-4`-methyl ether 7- O-α-L-rhamnopyranoside-8-C-β-D-glucopyranoside (1) and 1,7,8-trihydroxyanthraquinone 3-O-β -D-glucopyranoside (7), along with apigenin 7-O- β-D-glucpyranosyl-(1→6)-β-D-glucopyranoside (2), acacetin 7- O-α-L-rhamnopyranoside (3), luteolin 7-O- β-D-glucpyranosyl-(1→6)-β-D-glucopyranoside (4), luteolin 7-O- β-D-glucpyranoside (5), diosmetin 7- O-α-L-rhamnopyranoside (6). The structures of the isolated compounds were established by chromatographic and spectroscopic evidences. Pharmacological studies showed that the three doses of 70% aqueous methanolic extract of C. notabilis leaves (125, 250 and 500 mg/kg) have antidiabetic, analgesic, anti-inflammatory and antioxidant activity. | ||
| Keywords | ||
| Cassia notabilis; flavonoids; antidiabetic; anti-inflammatory; analgesic; antioxidant | ||
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