Association Between XRCC3 Thr241Met Gene Polymorphism and Susceptibility to Urothelial Carcinoma of the Bladder | ||
| Benha Medical Journal | ||
| Article 9, Volume 40, Issue 1, May and June 2023, Pages 97-109 PDF (804.15 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/bmfj.2022.177773.1721 | ||
| Authors | ||
| Enas S. Ahmed1; Neveen A. Abdulhafeez2; AYA ABDELAZIZ* 3; SHABIEB A ABDELBAKY4; ASMAA A. EL-FALLAH5 | ||
| 1Department of Clinical and Chemical Pathology Department, Faculty of Medicine, Benha University, Egypt | ||
| 2Clinical Pathology Department-Faculty Of Medicine-Benha University | ||
| 3Clinical & Chemical Pathology department, Faculty of Medicine, Benha University, Egypt | ||
| 4Urology department, Faculty of Medicine, Benha University, Egypt | ||
| 5assisat professor of Clinical and Chemical Pathology. Faculty of Medicine -Benha University | ||
| Abstract | ||
| Background: Bladder cancer is a very common malignancy worldwide its exact cause is not known, but it is believed to be multifactorial mostly caused by genetic mutations of tumor suppressor gene, proto-oncogenes and DNA repair genes including XRCC3 Thr241Met gene polymorphism. Aim of the study: Identify the link between XRCC3 (rs861539) gene polymorphism and the susceptibility to develop urothelial carcinoma of the bladder (UCB) in the Egyptian patients. Subjects and method: The presence of XRCC3 Thr241Met gene polymorphism (rs 861539) was identified by PCR-RFLP method in 50 patients with urothelial carcinoma of bladder and 50 healthy controls. Results: XRCC3 Thr 241 Met gene polymorphism CC genotype and C allele demonstrated a substantially increased susceptibility in the UCB group than the control group for the risk to develop UCB (OR 3.69, 95% CL 1.52-8.97) (P =0.003), however, while TT genotype and T allele demonstrated a substantially decreased susceptibility in the UCB group than the control group with a protective effect against UCB development (OR 0.096, 95%CL0.035-0.263) (P | ||
| Keywords | ||
| XRCC3; Gene polymorphism; Urothelial carcinoma of the bladder; Genotype; Allele | ||
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