Intravenous Diclofenac Sodium Versus Ibuprofen as A Component of Multimodal Post Operative Analgesic Plan After Caesarean Section: A Double-Blinded Randomised Comparative Study
Elawady, M., Ghonim, B., Lahloub, F., Hellal, D., Taman, H. (2022). Intravenous Diclofenac Sodium Versus Ibuprofen as A Component of Multimodal Post Operative Analgesic Plan After Caesarean Section: A Double-Blinded Randomised Comparative Study. EKB Journal Management System, 4(9), 2619-2626. doi: 10.21608/ijma.2022.172220.1540
Mostafa S. Elawady; Basma M. Ghonim; Fatma M. F. Lahloub; Doaa Hellal; Hani I. Taman. "Intravenous Diclofenac Sodium Versus Ibuprofen as A Component of Multimodal Post Operative Analgesic Plan After Caesarean Section: A Double-Blinded Randomised Comparative Study". EKB Journal Management System, 4, 9, 2022, 2619-2626. doi: 10.21608/ijma.2022.172220.1540
Elawady, M., Ghonim, B., Lahloub, F., Hellal, D., Taman, H. (2022). 'Intravenous Diclofenac Sodium Versus Ibuprofen as A Component of Multimodal Post Operative Analgesic Plan After Caesarean Section: A Double-Blinded Randomised Comparative Study', EKB Journal Management System, 4(9), pp. 2619-2626. doi: 10.21608/ijma.2022.172220.1540
Elawady, M., Ghonim, B., Lahloub, F., Hellal, D., Taman, H. Intravenous Diclofenac Sodium Versus Ibuprofen as A Component of Multimodal Post Operative Analgesic Plan After Caesarean Section: A Double-Blinded Randomised Comparative Study. EKB Journal Management System, 2022; 4(9): 2619-2626. doi: 10.21608/ijma.2022.172220.1540

Intravenous Diclofenac Sodium Versus Ibuprofen as A Component of Multimodal Post Operative Analgesic Plan After Caesarean Section: A Double-Blinded Randomised Comparative Study

International Journal of Medical Arts
Article 1, Volume 4, Issue 9, September 2022, Page 2619-2626  XML PDF (1019.25 K)
Document Type: Original Article
DOI: 10.21608/ijma.2022.172220.1540
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Authors
Mostafa S. Elawady email 1; Basma M. Ghonim2; Fatma M. F. Lahloub1; Doaa Hellal3; Hani I. Taman1
1Department of Anesthesia, Faculty of Medicine, Mansoura University, Mansoura, Egypt.
2Department of Anesthesia, Faculty of Medicine, Kafr Elsheikh University, Kafr Elsheikh, Egypt.
3Department of Clinical Pharmacology, Faculty of Medicine, Mansoura University, Mansoura, Egypt.
Abstract
Background: Postoperative pain has a significant direct relationship to morbidity of female patients after caesarean section. Adequate post caesarean section pain management is fundamental.  
Objectives: To compare the postoperative analgesic effect of both ibuprofen and diclofenac sodium on pain score, rescue opioid requirement and patient satisfaction in female patients after caesarean section.
Patients and methods: This prospective, randomised, double-blind comparative study was conducted over a period of eight months in Kafr Elsheikh University Hospital, obstetric unit. The study included any American Society of Anaesthesiologists [ASA] physical status II female patients aged 18–40 years who were scheduled for elective and emergency caesarean section under spinal anaesthesia. Patients were randomly allotted into two groups: Group D [intravenous diclofenac group] and Group I [intravenous ibuprofen group].
Results: First request of analgesics, total opioid consumption and VAS showed no significant differences between two groups except after 4hours and 8 hours postoperatively which showed significant decrease in diclofenac group than ibuprofen group. Also patient satisfaction was higher in Diclofenac group. There was increase in bleeding tendency [APTT, BT, and HB results] and abnormal abdominal bleeding attacks in diclofenac group.
Conclusion: Diclofenac decreases postoperative pain with higher potency than ibuprofen but unfortunately with more tendency to gastrointestinal complications and bleeding tendency.
Keywords
Postoperative; Pain management; Caesarian section; Bleeding
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