Metallothionein Protein Concentration in The Liver Tissue of Albino Mice Exposed to Cadmium and Zinc Chloride | ||
| The Egyptian Journal of Hospital Medicine | ||
| Article 298, Volume 89, Issue 2, October 2022, Pages 8083-8087 PDF (434.46 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/ejhm.2022.277596 | ||
| Authors | ||
| Enas Nihad Bayram; Nahla A. Al-Bakri; Hanady S. Al-Shmgani* | ||
| Department of Biology, College of Education for Pure Sciences (Ibn Al-Haitham) , University of Baghdad, Baghdad, Iraq | ||
| Abstract | ||
| Background: Cadmium (Cd), one of the most abundant heavy metals, is extremely toxic to both humans and animals. hIt is well known that zinc (Zn) administration reduces Cd-induced toxicity and that metallothioneins can have a protective effect in biological systems to mitigate Cd toxicity. Objective: The aim of the current study to determine if Zn administration affected the induction of MT-1 and MT-2 in the liver tissue in mice exposed to Cd. Materials and methods: Metallothionein protein (MT) level in the tissue of male mice were detected using the anion -exchang high-performance liquid chromatography coupled (HPLC)assay and immunohistochemical staining. Results: Single treatment to zinc or cadmium increase the level of MT in the liver, but zinc chloride treated significantly increase the level of MT after sub chronic treatment. Conclusion: Zinc pre-treatment with increasing the concentration of the dose of cadmium used in the co-treatment, and both of them may have worked together to induce a significant increase in protein synthesis to exceed the high toxicity of cadmium, by inducing an increase in MT protein synthesis. | ||
| Keywords | ||
| Cadmium; Zinc; Metallothionein; Liver; Mice; Experimental study; University of Baghdad | ||
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