Cytotoxic activity of some benzo[4,5]imidazo[1,2-a]pyrimidine derivatives against the human cancer cell lines HepG2 and MCF-7

Basyouni, Wahid; Abbas, Samir Youssef; El-bayouki, Khairy A.M; El-kady, Mohamed Y.; Abdelazeem, Nagwa M.; Dawood, Reham; Shemis, Mohamed A.

doi:10.21608/ejchem.2023.173878.7209

	Cytotoxic activity of some benzo[4,5]imidazo[1,2-a]pyrimidine derivatives against the human cancer cell lines HepG2 and MCF-7
Egyptian Journal of Chemistry
Volume 66, Issue 9, September 2023, Page 237-243 PDF (834.75 K)
Document Type: Original Article
DOI: 10.21608/ejchem.2023.173878.7209
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Authors
Wahid Basyouni ¹; Samir Youssef Abbas²; Khairy A.M El-bayouki ³; Mohamed Y. El-kady⁴; Nagwa M. Abdelazeem ⁵; Reham Dawood⁶; Mohamed A. Shemis⁷
¹National Research Centre
²Organometalic and Organometalliod Chemistry Department, National Research Centre
³Organometallic chemistry Department, National research centre
⁴Ain Shams university
⁵Organometallic and Organometalloid Chemistry Department, National Research Centre, Cairo, Egypt.
⁶Microbial Biotechnology Department, National Research Centre, Dokki, Cairo, Egypt
⁷Biochemistry and Molecular Biology Department, Theodor Bilharz Research Institute,Cairo, Egypt.
Abstract
Different benzo[4,5]imidazo[1,2-a]pyrimidine derivatives were synthesized in high purity and yields with short reaction times by the reaction of 2-aminobenzimidazole, aldehydes and active carbonyl compounds in the presence of Silica sulfuric acid/ethylene glycol (SSA/EG) as a catalyst. Cytotoxicity of the synthesized benzo[4,5]imidazo[1,2-a]pyrimidine derivatives 1-6 was carried out against the two human cancer cell lines, hepatocellular carcinoma (HepG2) and breast carcinoma (MCF-7) as well as Vero cells (normal cells).
Keywords
Benzo[4,5]imidazo[1,2-a]pyrimidine; Cytotoxicity; human cancer cell lines; Hepatocellular carcinoma; breast carcinoma


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