Human Leucocyte Antigen A Alleles in The Prediction of Post-Kidney Transplant Lymphoproliferative Disorders, A Single-Center Study
Magar, R., Fouda, M., Salama, O., Sabry, M., Refaie, A. (2023). Human Leucocyte Antigen A Alleles in The Prediction of Post-Kidney Transplant Lymphoproliferative Disorders, A Single-Center Study. EKB Journal Management System, 90(1), 262-267. doi: 10.21608/ejhm.2023.279537
Raghda W. Magar; Manal I. Fouda; Osama Salama; Mohamed Sabry; Ayman F. Refaie. "Human Leucocyte Antigen A Alleles in The Prediction of Post-Kidney Transplant Lymphoproliferative Disorders, A Single-Center Study". EKB Journal Management System, 90, 1, 2023, 262-267. doi: 10.21608/ejhm.2023.279537
Magar, R., Fouda, M., Salama, O., Sabry, M., Refaie, A. (2023). 'Human Leucocyte Antigen A Alleles in The Prediction of Post-Kidney Transplant Lymphoproliferative Disorders, A Single-Center Study', EKB Journal Management System, 90(1), pp. 262-267. doi: 10.21608/ejhm.2023.279537
Magar, R., Fouda, M., Salama, O., Sabry, M., Refaie, A. Human Leucocyte Antigen A Alleles in The Prediction of Post-Kidney Transplant Lymphoproliferative Disorders, A Single-Center Study. EKB Journal Management System, 2023; 90(1): 262-267. doi: 10.21608/ejhm.2023.279537

Human Leucocyte Antigen A Alleles in The Prediction of Post-Kidney Transplant Lymphoproliferative Disorders, A Single-Center Study

The Egyptian Journal of Hospital Medicine
Article 39, Volume 90, Issue 1, January 2023, Page 262-267  XML PDF (563.78 K)
DOI: 10.21608/ejhm.2023.279537
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Authors
Raghda W. Magar* 1; Manal I. Fouda2; Osama Salama2; Mohamed Sabry2; Ayman F. Refaie3
1)Urology and Nephrology Center
2Clinical Pathology Department, Faculty of Medicine, Mansoura University, Mansoura, Egypt
3Urology and Nephrology Center
Abstract
Background: Post-transplant lymphoproliferative disorders (PTLPD) are frequently encountered after kidney transplantation. Human leucocyte antigen (HLA)A alleles were shown to be a predictor of development of these disorders.
Objective: Study of prediction of human leucocyte antigen HLA-A alleles in the development of PTLPD.
Methods: This study included 50 Egyptian kidney transplant (KT) recipients who underwent live-donor kidney transplantation, between 2010 to 2022. HLA-A alleles phenotyping was characterized by sequence specific oligonucleotide probes (SSOP).  Nondestructive form of PTLPD was diagnosed by presence of lymphocytosis followed by assessment of, (CD45 and CD 19) mature B lymphocytes and blast cells (CD5 and CD10) with ratio of kappa/lambda by flow cytometry. The association between the development of this form and different HLA-A alleles was studied.
Results: Out of fifty recipients, five patients developed a non-destructive form of PTLPD in the median duration of 30 months (ranged, 15-50 months) post transplantation. A significant association was found between the expression of HLA-A01 (P=0.002, OR=1.020), CI (0.996-1.045) and HLA-A02 (P=0.042, OR=1.019), CI (1.001-1.037) and the development of PTLPD. Furthermore, HLA-A02 alleles were found to be a significant corelate with onset of development PTLPD.
Conclusion: Among Egyptian kidney transplant recipients, HLA-A01 and A02 alleles are good predictors of development of early non distractive form of PTLPD.
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