Comparative Protective Effects of L-Ascorbic Acid and Crude Honeybee Extract Supplements Against Toxic Effects Induced by Sodium Nitrate in Male Rats
Kamel, E., Mahmoud, H., Gad EL-Hak, H., Abdelrazek, H., Shebl, N., Mohamed, Y., Abd Elghany, G., Elrayess, R. (2023). Comparative Protective Effects of L-Ascorbic Acid and Crude Honeybee Extract Supplements Against Toxic Effects Induced by Sodium Nitrate in Male Rats. EKB Journal Management System, 90(1), 507-517. doi: 10.21608/ejhm.2023.279672
Eman Mohamed Kamel; Hany Salah. Mahmoud; Heba Nageh Gad EL-Hak; Heba M.A. Abdelrazek; Noha E. Shebl; Yousra Reda Arafa Mohamed; Ghada Mohamed Gad Abd Elghany; Ranwa Ahmed Abdou Elrayess. "Comparative Protective Effects of L-Ascorbic Acid and Crude Honeybee Extract Supplements Against Toxic Effects Induced by Sodium Nitrate in Male Rats". EKB Journal Management System, 90, 1, 2023, 507-517. doi: 10.21608/ejhm.2023.279672
Kamel, E., Mahmoud, H., Gad EL-Hak, H., Abdelrazek, H., Shebl, N., Mohamed, Y., Abd Elghany, G., Elrayess, R. (2023). 'Comparative Protective Effects of L-Ascorbic Acid and Crude Honeybee Extract Supplements Against Toxic Effects Induced by Sodium Nitrate in Male Rats', EKB Journal Management System, 90(1), pp. 507-517. doi: 10.21608/ejhm.2023.279672
Kamel, E., Mahmoud, H., Gad EL-Hak, H., Abdelrazek, H., Shebl, N., Mohamed, Y., Abd Elghany, G., Elrayess, R. Comparative Protective Effects of L-Ascorbic Acid and Crude Honeybee Extract Supplements Against Toxic Effects Induced by Sodium Nitrate in Male Rats. EKB Journal Management System, 2023; 90(1): 507-517. doi: 10.21608/ejhm.2023.279672

Comparative Protective Effects of L-Ascorbic Acid and Crude Honeybee Extract Supplements Against Toxic Effects Induced by Sodium Nitrate in Male Rats

The Egyptian Journal of Hospital Medicine
Article 71, Volume 90, Issue 1, January 2023, Page 507-517  XML PDF (1.08 MB)
Document Type: Original Article
DOI: 10.21608/ejhm.2023.279672
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Authors
Eman Mohamed Kamel; Hany Salah. Mahmoud; Heba Nageh Gad EL-Hak; Heba M.A. Abdelrazek; Noha E. Shebl; Yousra Reda Arafa Mohamed; Ghada Mohamed Gad Abd Elghany; Ranwa Ahmed Abdou Elrayess
Abstract
Background: Sodium nitrate has been used extensively as a meat additive to keep meat products fresh. Several strategies have been implemented in counteracting such toxicity.
Objective: The goal of the current investigation was to determine if ascorbic acid and crude honey extract can protect male rats from the harmful biochemical and histopathological effects of sodium nitrate.
Materials and methods: 36 male Albino rats were alienated into 6 groups; control was given saline, honey group was given (2.5g/kg/day honey, ascorbic group was given (200mg/kg /day) L-ascorbic acid, NaNO3 group was given 200mg/kg/day, honey/ NaNO3 group rats given honey and nitrate with the former doses, and Ascorbic/ NaNO3 group was given L-ascorbic acid and NaNO3 with the former doses. Organs’ relative weight, liver and kidney blood biochemical determinants, serum tumor necrosis factor alpha (TNF-α) and interleukin 6 (IL-6), histology and histochemistry were determined.
Results: The sodium nitrate had significantly increased liver, kidney and spleen relative weights while decreased thymus weight. Higher levels of AST, ALT, urea, creatinine, IL-6 and TNF-α were observed in NaNO3 treated group. Liver, kidney, and spleen of rats treated with NaNO3 revealed histological and histochemical alterations. The treatment with L-ascorbic acid and crude honeybee improved the later dysfunctions with more palliative effect for L-ascorbic acid.
Conclusions: We can conclude that sodium nitrate has to be limited in use. L-ascorbic acid was therefore recommended to be used in reducing the harmful metabolic alterations induced by sodium nitrate better than the honeybee.
 
Keywords
Ascorbic acid; Honey; Kidney; Liver; Sodium nitrite; Spleen
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