EFFECT OF LONG-TIME MALATHION ADMINISTRATION ON TESTOSTERONE, OXIDATIVE STRESS, AND SPERM CHARACTERISTICS IN RATS | ||||
| Assiut Veterinary Medical Journal | ||||
| Article 5, Volume 69, Issue 176, January 2023, Page 55-64 PDF (752.91 K) | ||||
| Document Type: Research article | ||||
| DOI: 10.21608/avmj.2023.161565.1090 | ||||
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| Authors | ||||
MARWA A. GABER1; TAHIA HASHIM SALEEM1; AHMED Y. NASSAR 1; HEBA F. HOZYEN2; MAHMOUD GAMAL MAHMOUD  3; HASSAN ABDEL-SABOUR ALI HUSSEIN4
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| 1Department of Medical Biochemistry Faculty of Medicine Assiut University, Assiut, 71526, Egypt | ||||
| 2Animal Reproduction and Artificial Insemination National Research Centre, Giza,12622, Egypt | ||||
| 3Department of Medical Biochemistry Faculty of Veterinary Medicine Assiut University, Assiut, 71526, Egypt | ||||
| 4Department of Theriogenology Faculty of Veterinary Medicine Assiut University, Assiut, 71526, Egypt | ||||
| Abstract | ||||
| Organophosphorus pesticides are one of the most extensively used forms of pesticides that could adversely impact fertility in both animals and humans. The current research aimed to investigate the potential effects of long-time malathion administration on testosterone in serum, oxidative stress biomarkers in testicular tissue and sperm characteristics of rats as an experimental model. Twenty adult male Wistar rats were split into two groups: the control group (n = 10) and the malathion-treated group (n = 10) based on the medication received orally by gavage (3 times/week for 60 days). Long-time administration of malathion negatively affected testosterone level, sperm count, sperm viability, and sperm morphology when compared to the control group. Lipid peroxidation increased significantly in the malathion-treated group when compared to the control group. On the other hand, Malathion administration caused a significant reduction in testosterone level, activities of glutathione peroxidase, reduced glutathione, and superoxide dismutase enzymes in testicular tissue of male rats. In conclusion, long-term administration of malathion had deleterious effects on testosterone level and testicular oxidative status as well as semen quality in male rats. | ||||
| Keywords | ||||
| Malathion; oxidative status; semen quality; testes; and male rats | ||||
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