Antimicrobial Benzofuran Derivatives and Chemosystematic Significance of Senecio glaucus L. (Asteraceae) | ||
| Egyptian Journal of Chemistry | ||
| Volume 66, Issue 10, October 2023, Pages 575-583 PDF (560.49 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/ejchem.2023.168069.7076 | ||
| Authors | ||
| Taha A. Hussien1; Dina A. El-Amir2; Usama A. A. Radwan2; Magdi A. El-Sayed2, 3; Abou El-Hamd H. Mohamed* 4; Hussein El-Damarany4 | ||
| 1Department of Pharmacognosy, Faculty of Pharmacy, Sphinx University, Assiut, Egypt, | ||
| 2Department of Botany, Faculty of Science, Aswan University, Egypt, | ||
| 3Department of Biological Science, Molecular Biotechnology program, Field of Advanced Basic Sciences, Galala University, New Galala City, Egypt, | ||
| 4Department of Chemistry, Faculty of Science, Aswan University, Egypt | ||
| Abstract | ||
| Phytochemical investigation of methylenechloride/methanol (1:1) extract of the air-dried aerial parts of Senecio glaucus L. afforded three benzofuran derivatives (1-3); 1-(6-hydroxy-2-(prop-1-en-2-yl) benzofuran-5-yl) ethanone, 1-1'-(6-hydroxybenzofuran-2,5-diyl) diethanone, and 1-1'-(6-methoxybenzofuran-2,5-diyl) diethanone. The crude extract and isolated compounds (1-3) were screened against S. aureus and E. coli and also against C. albicans and A. flavus. Compound 1 and 2 were more potent than 3 against S. aureus and E. coli, however, the crude extract and isolated compounds (1-3) showed weak antifungal activity against C. albicans and A. flavus. In addition, a biosynthetic pathway of isolated compounds (1-3) was proposed, as well as the chemotaxonomic significance of the reported benzofuran and furanoeremophilane derivatives from S. glaucus compared to those isolated from other Senecio species was also studied. | ||
| Keywords | ||
| Senecio glaucus; Chemosystematic significance; Biosynthetic pathway; Antimicrobial Benzofuran derivatives | ||
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