The use of injectable plasma rich fibrin (I-PRF) versus simvastatin gel in surgical management of infra-bony defects (A Randomized Controlled Clinical Trial) | ||
| Egyptian Dental Journal | ||
| Article 17, Volume 69, Issue 1 - Serial Number 3, January 2023, Pages 353-362 PDF (851.79 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/edj.2022.168262.2312 | ||
| Authors | ||
| Nada Saleh* 1; Suzan Ibrahim2; Ola Ezzatt3 | ||
| 1Oral Medicine, Periodontology, Oral Diagnosis and Radiology Department, Faculty of Dentistry, Ain Shams University. | ||
| 2Associate Professor, Oral Medicine, Periodontology, Oral Diagnosis and Radiology Department, Faculty of Dentistry, Ain Shams University | ||
| 3Professor, Oral Medicine, Periodontology, Oral Diagnosis and Radiology Department, Faculty of Dentistry, Ain Shams University | ||
| Abstract | ||
| Objectives: Numerous studies have described the benefits of the injectable plasma rich fibrin (I-PRF) and simvastatin (SMV) gel separately in periodontal regeneration. However, there has been a lack of clinical trials comparing the use of these two agents. The aim of this study was to compare the clinical efficacy of open flap debridement (OFD) either with (I-PRF) or 1.2 % (SMV) gel in the management of patients having infra-bony defects (IBDs). Subjects and methods: Twenty patients, having stage III grade B periodontitis with (IBDs) were recruited and randomly allocated to either; Group I (I-PRF) (n=10) undergoing (OFD) followed by single application of I-PRF, or Group II (SMV) (n=10) undergoing (OFD) followed by application of 1.2% simvastatin gel. The following clinical parameters were measured at baseline, and 6 months post-operative; clinical attachment level (CAL), periodontal pocket depth (PD), plaque index (PI) and gingival index (GI), as clinical parameters as well as, defect depth as a radiographic parameter. Results: Both groups showed significant reduction regarding all clinical parameters with no statistically significant difference between groups at 6 months post-operative. SMV demonstrated a statistically significant higher reduction in defect depth compared to I-PRF. Conclusion: I-PRF and SMV 1.2% gel as adjunctive local delivery regenerative therapy to (OPD) were effective and comparable clinically. Infrabony defects treated with SMV 1.2 % gel showed better bone fill compared to I-PRF radiographically. | ||
| Keywords | ||
| Infrabony defects; I-PRF; Periodontitis; Simvastatin; Stage III grade B | ||
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