A prospective clinical study to compare between the role of Rosuvastatin against Nigella Sativa (N sativa) in protection of azithromycin toxicity in covid-19 patients in isolation centers, Minia Governorate, Egypt | ||
| Ain Shams Journal of Forensic Medicine and Clinical Toxicology | ||
| Volume 40, Issue 1, January 2023, Pages 61-67 PDF (1.34 M) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/ajfm.2023.281727 | ||
| Authors | ||
| Mohamed Hafez1; Enas Abdel Azeem1; Esraa Abdel Magid1; Amr Abdel Hafeez2; Eman Mahmoud1 | ||
| 1Department of Forensic Medicine & Clinical Toxicology, Faculty of Medicine, Minia University. | ||
| 2Department of Cardiology, Faculty of Medicine, Minia University. | ||
| Abstract | ||
| Background: Azithromycin is the most common antibiotic used nowadays. Objectives: To evaluate the cardio-toxicity of azithromycin and to assess the effect of Nigella Sativa (N Sativa) and Rosuvastatin in cardio-protection. Patient & methods: This clinical prospective study was carried out on adult patients diagnosed as positive COVID-19 and was admitted to isolation centers in Minia Governorate during the period from 1st of June 2021 to 30th of May 2022. It included 160 patients divided into 4 groups. Group I received 500 mg/ 24 hours (hrs) of azithromycin orally for five days, group II received 500 mg/ 24hrs of azithromycin + 20 mg/ day of Rosuvastatin orally for five days, group III also received 500 mg/ 24hrs of azithromycin + 4 ml/ kg/ 24hrs N Sativa orally for five days, group IV received the same previously mentioned doses and duration of azithromycin, Rosuvastatin and N Sativa. Full clinical examination was done, electrocardiogram (ECG) was performed and venous blood samples were drawn for estimation of CK-MB level from all patients before and after the treatment. Result: Patients aged 32- 59 years old, 62 were females and 98 were males. Significant elevation of CK-MB in group I after treatment with azithromycin comparing with before treatment in the same group (p<0.01) was detected. There were significant differences in all groups between pre and posttreatment regards QT interval (p<0.01). Conclusion: Azithromycin had toxic effect on the heart, Rosuvastatin was better than N Sativa in treating this toxic effect. Treatment with Rosuvastatin + N Sativa together leads to the best results. Recommendation of this study is taking of Rosuvastatin plus N Sativa during the treatment with azithromycin. Received in original form: 20 October 2022 Accepted in a final form: 20 January 2023 | ||
| Keywords | ||
| Azithromycin; Rosuvastatin; N Sativa; CK-MB, ECG | ||
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