A prospective clinical study to compare between the role of Rosuvastatin against Nigella Sativa (N sativa) in protection of azithromycin toxicity in covid-19 patients in isolation centers, Minia Governorate, Egypt
Hafez, M., Abdel Azeem, E., Abdel Magid, E., Abdel Hafeez, A., Mahmoud, E. (2023). A prospective clinical study to compare between the role of Rosuvastatin against Nigella Sativa (N sativa) in protection of azithromycin toxicity in covid-19 patients in isolation centers, Minia Governorate, Egypt. EKB Journal Management System, 40(1), 61-67. doi: 10.21608/ajfm.2023.281727
Mohamed Hafez; Enas Abdel Azeem; Esraa Abdel Magid; Amr Abdel Hafeez; Eman Mahmoud. "A prospective clinical study to compare between the role of Rosuvastatin against Nigella Sativa (N sativa) in protection of azithromycin toxicity in covid-19 patients in isolation centers, Minia Governorate, Egypt". EKB Journal Management System, 40, 1, 2023, 61-67. doi: 10.21608/ajfm.2023.281727
Hafez, M., Abdel Azeem, E., Abdel Magid, E., Abdel Hafeez, A., Mahmoud, E. (2023). 'A prospective clinical study to compare between the role of Rosuvastatin against Nigella Sativa (N sativa) in protection of azithromycin toxicity in covid-19 patients in isolation centers, Minia Governorate, Egypt', EKB Journal Management System, 40(1), pp. 61-67. doi: 10.21608/ajfm.2023.281727
Hafez, M., Abdel Azeem, E., Abdel Magid, E., Abdel Hafeez, A., Mahmoud, E. A prospective clinical study to compare between the role of Rosuvastatin against Nigella Sativa (N sativa) in protection of azithromycin toxicity in covid-19 patients in isolation centers, Minia Governorate, Egypt. EKB Journal Management System, 2023; 40(1): 61-67. doi: 10.21608/ajfm.2023.281727

A prospective clinical study to compare between the role of Rosuvastatin against Nigella Sativa (N sativa) in protection of azithromycin toxicity in covid-19 patients in isolation centers, Minia Governorate, Egypt

Ain Shams Journal of Forensic Medicine and Clinical Toxicology
Volume 40, Issue 1, January 2023, Page 61-67  XML PDF (1.34 MB)
Document Type: Original Article
DOI: 10.21608/ajfm.2023.281727
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Authors
Mohamed Hafez1; Enas Abdel Azeem1; Esraa Abdel Magid1; Amr Abdel Hafeez2; Eman Mahmoud1
1Department of Forensic Medicine & Clinical Toxicology, Faculty of Medicine, Minia University.
2Department of Cardiology, Faculty of Medicine, Minia University.
Abstract
Background: Azithromycin is the most common antibiotic used nowadays. Objectives: To 
evaluate the cardio-toxicity of azithromycin and to assess the effect of Nigella Sativa (N Sativa) 
and Rosuvastatin in cardio-protection. Patient & methods: This clinical prospective study was 
carried out on adult patients diagnosed as positive COVID-19 and was admitted to isolation 
centers in Minia Governorate during the period from 1st of June 2021 to 30th of May 2022. It 
included 160 patients divided into 4 groups. Group I received 500 mg/ 24 hours (hrs) of 
azithromycin orally for five days, group II received 500 mg/ 24hrs of azithromycin + 20 mg/ day 
of Rosuvastatin orally for five days, group III also received 500 mg/ 24hrs of azithromycin + 4 
ml/ kg/ 24hrs N Sativa orally for five days, group IV received the same previously mentioned 
doses and duration of azithromycin, Rosuvastatin and N Sativa. Full clinical examination was 
done, electrocardiogram (ECG) was performed and venous blood samples were drawn for
estimation of CK-MB level from all patients before and after the treatment. Result: Patients 
aged 32- 59 years old, 62 were females and 98 were males. Significant elevation of CK-MB in 
group I after treatment with azithromycin comparing with before treatment in the same group 
(p<0.01) was detected. There were significant differences in all groups between pre and posttreatment regards QT interval (p<0.01). Conclusion: Azithromycin had toxic effect on the heart, 
Rosuvastatin was better than N Sativa in treating this toxic effect. Treatment with Rosuvastatin + 
N Sativa together leads to the best results. Recommendation of this study is taking of 
Rosuvastatin plus N Sativa during the treatment with azithromycin. 
Received in original form: 20 October 2022 Accepted in a final form: 20 January 2023
Keywords
Azithromycin; Rosuvastatin; N Sativa; CK-MB, ECG
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