ASSOCIATION OF PLASMA (U2) SMALL NUCLEAR RNA FRAGMENTS AND COLORECTAL CANCER IN A COHORT OF EGYPTIAN PATIENTS | ||
| ALEXMED ePosters | ||
| Article 1, Volume 5, Issue 1, January 2023, Pages 14-15 | ||
| Document Type: Preliminary preprint short reports of original research | ||
| DOI: 10.21608/alexpo.2023.188710.1548 | ||
| Authors | ||
| Doaa Ibrahim Hahad1; Eman Tayea Dessouky2; Ahmed Abdelfattah Sabry3; Maha Moustafa Mohamed Mohsen* 4 | ||
| 1clinical and chemical pathology, Alexandria faculty of edicine, Alexandria University, Alexandria, Egypt | ||
| 2Clinical and chemical pathology, Alexandria Faculty of medicine, Alexandria University, Alexandria, Egypt | ||
| 3Department of Git surgery, faculty of medicine, Alexandria university | ||
| 4Department of Clinical and Chemical Pathology, Faculty of Medicine, Alexandria University | ||
| Abstract | ||
| • Colorectal cancer (CRC) is the third most common malignancy worldwide • In Egypt, CRC is the 7th commonest cancer. • The CRC is the second deadliest cancer worldwide. • Screening for early cancer stages is an effective way to reduce cancer mortality • Development of new biomarkers for noninvasive screening procedures is aid to early diagnosis of cancers and to help in reducing mortality and morbidity. • Non-coding RNA is a functional RNA that does not encode a protein • Non-coding RNAs are classified into small non-coding RNAs such as small nuclear RNA (snRNA) and long non-coding RNAs • SnRNAs are known as U small nuclear RNA • U2 snRNA fragments proved to be highly stable in the serum, plasma and other body fluids from cancer patients and could be detected by a simple routine PCR-based assay • Detection of U2 snRNA fragments in the blood can also hold promise for detecting some cancer types at a curable stage. | ||
| Keywords | ||
| Colorectal cancer (CRC); U2 snRNA fragments; PCR-based assay | ||
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