Subcutaneous Versus Intranodal Dendritic Cells- DRibbles Vaccination of Hepatocellular Carcinoma in Animal Model | ||
| Egyptian Journal of Medical Microbiology | ||
| Volume 28, Issue 3, July 2019, Pages 149-154 PDF (372.06 K) | ||
| Document Type: New and original researches in the field of Microbiology. | ||
| DOI: 10.21608/ejmm.2019.283185 | ||
| Authors | ||
| Awny A. Gawish; Takwa E. Meawed; Alia A. El Shahaway; Naglaa M. Ahmed* | ||
| Department Medical of Microbiology& Immunology, Zagazig University, Egypt | ||
| Abstract | ||
| Background: Cancer immunotherapy became a promising alternative to old therapeutic options in hepatocellular carcinoma. DC-DRibbles vaccine has clinical applications across a broad range of malignancies. Objective: To compare the efficacy of subcutaneous and intranodal routes of injection of Dendritic Cells-DRibbles immunotherapy in HCC induced mice. Methodology: This experimental study was conducted on 24 BALB/c mice. Healthy as negative control and cancer induced. The later was subdivided into two groups: positive control group and vaccinated groups (A and B) according to route of administration. Results: The mean of percentage of tumor volume reduction was 92.76% in DC+ Dribbles intranodal group (B), which was better than mean of percentage of change in subcutaneous group (A) which was 90.87%. Conclusion: DC- Dribbles vaccine was effective as HCC immunotherapy, both subcutaneous and intra nodal routes had comparable results. This study recommends subcutaneous route over intranodal route immunotherapy; it is simple, less invasive and effective. | ||
| Keywords | ||
| Autophagy; dendritic cells; hepatocellular carcinoma; antitumor immune response | ||
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