Thermogravimetric analysis and decomposition kinetics of velpatasvir co-povidone under non-isothermal conditions
EL-Shorbagy, H., Mohamed, M., El-Gendy, A., Belal, F., Hadad, G. (2023). Thermogravimetric analysis and decomposition kinetics of velpatasvir co-povidone under non-isothermal conditions. EKB Journal Management System, 7(1), 27-33. doi: 10.21608/rpbs.2023.166748.1177
Hanan Ibrahim EL-Shorbagy; Mona Mohamed; Alaa El-Gendy; Fathalla Belal; Ghada Hadad. "Thermogravimetric analysis and decomposition kinetics of velpatasvir co-povidone under non-isothermal conditions". EKB Journal Management System, 7, 1, 2023, 27-33. doi: 10.21608/rpbs.2023.166748.1177
EL-Shorbagy, H., Mohamed, M., El-Gendy, A., Belal, F., Hadad, G. (2023). 'Thermogravimetric analysis and decomposition kinetics of velpatasvir co-povidone under non-isothermal conditions', EKB Journal Management System, 7(1), pp. 27-33. doi: 10.21608/rpbs.2023.166748.1177
EL-Shorbagy, H., Mohamed, M., El-Gendy, A., Belal, F., Hadad, G. Thermogravimetric analysis and decomposition kinetics of velpatasvir co-povidone under non-isothermal conditions. EKB Journal Management System, 2023; 7(1): 27-33. doi: 10.21608/rpbs.2023.166748.1177

Thermogravimetric analysis and decomposition kinetics of velpatasvir co-povidone under non-isothermal conditions

Records of Pharmaceutical and Biomedical Sciences
Volume 7, Issue 1, January 2023, Pages 27-33    PDF (912.86 K)
Document Type: Original Article
DOI: 10.21608/rpbs.2023.166748.1177
Authors
Hanan Ibrahim EL-Shorbagy* 1; Mona Mohamed2; Alaa El-Gendy3; Fathalla Belal4; Ghada Hadad5
1Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt
2Pharmaceutical Chemistry Department, National Organization for Drug Control and Research (NODCAR), Giza, Egypt
3Faculty of Pharmacy - Suez Canal University
4Faculty of Pharmacy -Mansora University
5Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, Suez Canal University, Ismailia 41522, Egypt
Abstract
The thermal decomposition of velpatasvir:copovidone (1:1) was studied by simultaneous thermogravimetry/derivative thermogravimetry (TG/DTG). The influence of the heating rate (10 oC min-1) on the TG was verified. For the determination of kinetic parameters from the TG/DTG curves, the following methods were utilized: Arrhenius equation, Horwitz–Metzger, and Coats–Redfern methods. The kinetic studies of velpatasvir copovidone showed a thermal behavior characteristic of first order according to the activation energy. The activation energy obtained was found to be about 99.93±9.09 kJ mol-1. The TGA/DTG curves demonstrate that the drug undergoes two phases of thermal decomposition. The first is due to the dehydration of copovidone. The second phase occurs at three thermal decomposition steps. The first thermal decomposition step occurred at an interval of 210.0–407.0 oC. The second thermal decomposition step occurs in the interval of 407.0–465.0 oC. The third thermal decomposition step occurs in the interval of 465.0–621.0 oC, which may be attributed to the complete thermal decomposition.
Keywords
Velpatasvir; Copovidone; Kinetic parameters; Non-isothermal; TG/DTG
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