Synthesis, Reactions, and Antimicrobial Activity of N-Hydroxy-triacetonamine Derivatives | ||
| Egyptian Journal of Chemistry | ||
| Article 1, Volume 62, Issue 8, August 2019, Pages 1359-1366 PDF (1.14 M) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/ejchem.2019.7103.1586 | ||
| Authors | ||
| Mahmoud N. M. Yousif* 1; Ahmed A. Fayed2; Nabil N Yousif3 | ||
| 1Department of Photochemistry, National Research Centre, Cairo, Egypt | ||
| 2Photochemistry Depatment, National Research Centre, Cairo, Egypt. | ||
| 3Photochemistry Department, National Research Centre, Egypt | ||
| Abstract | ||
| Simple and one step method for preparation of N-hydroxy-2,2,6,6-tetramethyl-4-piperidone is reported. N-Hydroxy-2,2,6,6-tetramethyl-4-piperidone (1) reacts with formaldehyde, formaldehyde and piperidine to afford compounds (3) and (4) respectively. Compound (1) reacts with sodium azide and α-bromosugar to afford corresponding products. Compound (1) reacts with 2-(4-chlorobenzylidene)malononitrile to afford 1,6-napthyridine derivative (9). N-Hydroxy-2,2,6,6-tetramethyl-4-piperidone (1) reacts with p-chlorobenzaldehyde and cyanoacetamide to produce 1,6-napthyridine derivative (10a). N-Hydroxy derivative (1) reacts also with p-chlorobenzaldehyde and ethylcyanoacetate to afford 1,6-napthyridine (10b). Antimicrobial screening of some of the synthesized compounds has been performed. | ||
| Keywords | ||
| 2; 6; 6-Tetramethyl-4-piperidone; triacetonamine; N-hydroxy-triacetonamine; Formaldehyde | ||
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