Synthesis, Reactions, and Antimicrobial Activity of N-Hydroxy-triacetonamine Derivatives | ||||
| Egyptian Journal of Chemistry | ||||
| Article 1, Volume 62, Issue 8, August 2019, Page 1359-1366 PDF (1.14 MB) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ejchem.2019.7103.1586 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
Mahmoud N. M. Yousif  1; Ahmed A. Fayed2; Nabil N Yousif3
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| 1Department of Photochemistry, National Research Centre, Cairo, Egypt | ||||
| 2Photochemistry Depatment, National Research Centre, Cairo, Egypt. | ||||
| 3Photochemistry Department, National Research Centre, Egypt | ||||
| Abstract | ||||
| Simple and one step method for preparation of N-hydroxy-2,2,6,6-tetramethyl-4-piperidone is reported. N-Hydroxy-2,2,6,6-tetramethyl-4-piperidone (1) reacts with formaldehyde, formaldehyde and piperidine to afford compounds (3) and (4) respectively. Compound (1) reacts with sodium azide and α-bromosugar to afford corresponding products. Compound (1) reacts with 2-(4-chlorobenzylidene)malononitrile to afford 1,6-napthyridine derivative (9). N-Hydroxy-2,2,6,6-tetramethyl-4-piperidone (1) reacts with p-chlorobenzaldehyde and cyanoacetamide to produce 1,6-napthyridine derivative (10a). N-Hydroxy derivative (1) reacts also with p-chlorobenzaldehyde and ethylcyanoacetate to afford 1,6-napthyridine (10b). Antimicrobial screening of some of the synthesized compounds has been performed. | ||||
| Keywords | ||||
| 2; 6; 6-Tetramethyl-4-piperidone; triacetonamine; N-hydroxy-triacetonamine; Formaldehyde | ||||
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