Clinicopathological Significance of A20 Genetic Mutation in Diffuse Large B-Cell Lymphoma | ||
| The Egyptian Journal of Hospital Medicine | ||
| Article 252, Volume 90, Issue 1, January 2023, Pages 1680-1683 PDF (550.64 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/ejhm.2023.283683 | ||
| Authors | ||
| Rana M. Shaat* ; Hasan A. Abd El Ghaffar; Sameh Shamaa; Hanaa M. Abdel-Masseih; Osama Elbaz | ||
| Abstract | ||
| Background: Activation of pathway of nuclear factor kappaB (NF-κB) which is caused by genetic alterations has been reported in B cell lymphoma. A20 gene is considered main regulator component of NF-κB signaling. Its function is mainly suppression of this pathway. Deletions and/or mutations in A20 gene cause inactivation of this pathway which were found in various hematologic malignancies. Objective: The current study aims to determine the prevalence of A20 gene mutations and their relationship with the clinical and laboratory profile in diffuse large B-cell lymphoma (DLBCL). Patients and methods: A total 100 DLBCL patients were investigated for A20 gene mutation by real time polymerase chain reaction. Results: A20 gene mutation GA mutant genotype was found in 18% of the patients, where 77.8% of them were ABC-DLBCL subtypes. GA heterozygous genotype was frequently associated with stage IV and extra-nodal infiltration, and shorter overall survival (OS). Conclusion: Our study suggests a role of A20 gene mutation in DLBCL pathogenesis as well as its prognosis. | ||
| Keywords | ||
| Tumor necrosis factor alpha induced protein3; Nuclear Factor kB; Diffuse large B-cell lymphoma; Case series; Mansoura University | ||
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