PHYTOCONSTITUENTS AND BIOLOGICAL EVALUATION OF JUSTICIA SPICIGERA CULTIVATED IN EGYPT | ||||
| Al-Azhar Journal of Pharmaceutical Sciences | ||||
| Article 2, Volume 56, Issue 2, September and October 2017, Page 10-19 PDF (548.44 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ajps.2017.28456 | ||||
 View on SCiNiTO | ||||
| Author | ||||
| Ahmed Othman | ||||
| Pharmacognosy Department, Faculty of Pharmacy, Al-Azhar University, Cairo, Egypt | ||||
| Abstract | ||||
| Four compounds were isolated from the aerial parts of Justicia spicigera Schltdl. (Acanthaceae) and were identified as uracil (1), uridine (2),megastigmane vomifoliol-9-O-β-D-Glucopyranoside (3) and β-sitosterol (4). The structures of these compounds were characterized by spectroscopic methods (IR, 1H-NMR, APT, 2D NMR and EI/MS). The different crude extracts showed selective inhibitory activity against Mycobacterium tuberculosis (TB), remarkable cytotoxic activities against Human breast cancer (MCF-7) cell lines and Human lung carcinoma (A-549) cell lines and weak antimicrobial activities. This is the first report concerning the isolation of compounds (1-3) from genus Justicia. | ||||
| Keywords | ||||
| Justicia spicigera; phytoconstituents; Anti-TB and Cytotoxicity | ||||
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