Histopathological Study of the Chronic Toxic Effects of Dapoxetine Administration on Testes of Male Albino Rats | ||
| The Egyptian Journal of Hospital Medicine | ||
| Article 3, Volume 74, Issue 8, January 2019, Pages 1698-1701 PDF (496.7 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/ejhm.2019.28521 | ||
| Authors | ||
| Mohammed Fathy Assasa; Esam Said Mohammed; Osama Moustafa Moustafa; Ahmed Mohammed Albuomy Abo Alfotoh* | ||
| Department of Forensic Medicine and Clinical Toxicology, Faculty of Medicine, Al-Azhar University, Cairo, Egypt | ||
| Abstract | ||
| Background: Dapoxetine is a short acting oral SSRI, purely created for the on-demand treatment of premature ejaculation. The present study was carried out to see the histopathological effects of Dapoxetine on the testis of adult albino rats. Materials and methods: Dapoxetine was administered orally by gavage to rats for consecutive 70 days, Eighty apparently healthy male albino rats weighing 125–150 g were used throughout the experiments .The rats were divided randomly into four groups (n=6). Each group 20 rats: Group (1) Control group, Group (2) receiving 1 mg of dapoxetine /70 days, Group (3) receiving 5 mg of dapoxetine /70 days and Group (4) receiving 10 mg of dapoxetine /70 days. Histological slides were prepared and stained with H and E stain. On examination, distortion of seminiferous tubules, decreased thickness of germinal epithelium, decreased diameter of seminiferous tubules and decreased counts of germinal cell lineage were found in treated groups. | ||
| Keywords | ||
| dapoxtine; histopathological effects; ssri | ||
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