Effect of Phoenix dactylifera seeds extract on cadmium-induced hepatotoxicity in male mice | ||
| Journal of Bioscience and Applied Research | ||
| Volume 9, Issue 1, March 2023, Pages 53-61 PDF (688.05 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/jbaar.2023.285435 | ||
| Authors | ||
| Karim Samy El-Said* ; Walaa Abasery Amoush; Amro El-Sherbeni Mohamed | ||
| Biochemistry Division, Chemistry Department, Faculty of Science, Tanta University, Egypt | ||
| Abstract | ||
| Heavy metals are common contaminants that have negative impacts on the body's organs and systems. Date (Phoenix dactylifera) has a great interest in biomedical applications and traditional medicine for the management of several diseases. This study evaluated the impact of Phoenix dactylifera seed extract (PDSE) on cadmium (Cd)-induced hepatotoxicity in mice. Fifty mice were equally divided into five groups, G1 was negative control, G2 was injected i.p. with PDSE (300 mg/kg b.wt) daily, G3 was injected i.p. with Cd (6.5 mg/kg b.wt) daily, G4 was injected with Cd and PDSE as in G2 and 3, respectively. G5 was injected with Cd as in G3 and then with EDTA (25 mg/kg b.wt). On day 15, sera samples were collected for biochemical parameters assessment. Liver tissues were collected for the determination of oxidants/antioxidants biomarkers and histopathological investigations. The results showed that treatment with PDSE significantly ameliorated the hepatic dysfunctions in the Cd-intoxicated mice evidenced by significant improvement in the ALT, AST, ALP, and total protein levels as well as in the total bilirubin and GGT levels. Furthermore, there was a significant increase in the SOD and CAT activities with a significant decrease in MDA levels after treatment of Cd-injected mice with PDSE. Also, treatment with PDSE resulted in improvement in the hepatic architectures alterations induced by Cd. PDSE showed promising metal chelating activities in vitro and in Cd-intoxicated mice by ameliorating biochemical and histopathological alterations in the liver tissues induced by Cd of mice. | ||
| Keywords | ||
| Phoenix dactylifera; Heavy metals; Cadmium; Hepatotoxicity | ||
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