Mean Platelet Volume as a Biomarker for Detection of Reperfusion Abnormalities in STEMI Patients Treated with Primary PC | ||||
| The Medical Journal of Cairo University | ||||
| Volume 90, Issue 12, December 2022, Page 2143-2150 PDF (338.79 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/mjcu.2022.287345 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
| MAHMOD H. SHAH, M.D.; GHADA I. MOHAMED, M.D.; MOHAMED E. MOHAMED, M.Sc.; BAHER N. NASHY, M.D. | ||||
| The Department of Cardiology, Faculty of Medicine, Zagazig University | ||||
| Abstract | ||||
| Abstract Background: ST-Segment Elevation Myocardial Infarction (STEMI) is one a common presentation of cardiovascular diseases. About 40% of patients with (ACS) presented as STEMI. Prevalence of STEMI continues to rise in worldwide [1]. Platelets (PLT) have a central role in pathophysiology of ACS [2]. And a major role in development of no-reflow [6]. Furthermore, increased mean platelet volume (MPV) at ad-mission was associated with long-term mortality in patients with ACS [7]. Aim of Study: We aimed to evaluate the accuracy of MPV as a biomarker for detection of reperfusion abnormalities in STEMI patients treated with primary PCI. Patients and Methods: This study was conducted at Zagazig University Hospital on 100 consecutive STEMI patients who underwent primary PCI, blood samples obtained on admission, ECG, Echocardiography were done; those patients were divided into two groups; 80 patients who expe-rienced successful reperfusion, and 20 patients who did not. Results: Post PCI corrected TIMI frame count (CTFC) was correlated with MPV post and pre-PCI as well as MPV; (p=0.005) where patients with high mean platelet volume (MPV) had significant increase in (CTFC). MPV before and after PCI were significantly higher in unsuccessful reperfusion group compared to successful reper-fusion group. MPV showed s gnificant r duction in thethe successful reperfusion group compared to unsuccessful group (p<0.05). MPV, systolic wall motion score (SWM score) and door-to-wire time were significant and independent predictors for unsuccessful reperfusion in STEMI patients treated by primary PCI. Conclusion: Mean platelet volume estimated before, after PCI and MPV are useful biomarkers and showed high accuracy for prediction of unsuccessful reperfusion after primary PCI in STEMI patients. | ||||
| Keywords | ||||
| Mean platelet volume; STEMI; Primary PCI; Unsuccessful reperfusion | ||||
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