Diagnostic Utility of Serum Copeptin Level in Children with Febrile Seizures
Abdulhafith, A., Siam, A., Mohammed, A., Risha, A. (2023). Diagnostic Utility of Serum Copeptin Level in Children with Febrile Seizures. EKB Journal Management System, 90(2), 3022-3026. doi: 10.21608/ejhm.2023.288377
Ammar Ali Ammar Abdulhafith; Ahmed Galal Siam; Ahmed Abdel Sabour Mohammed; AMR I. Risha. "Diagnostic Utility of Serum Copeptin Level in Children with Febrile Seizures". EKB Journal Management System, 90, 2, 2023, 3022-3026. doi: 10.21608/ejhm.2023.288377
Abdulhafith, A., Siam, A., Mohammed, A., Risha, A. (2023). 'Diagnostic Utility of Serum Copeptin Level in Children with Febrile Seizures', EKB Journal Management System, 90(2), pp. 3022-3026. doi: 10.21608/ejhm.2023.288377
Abdulhafith, A., Siam, A., Mohammed, A., Risha, A. Diagnostic Utility of Serum Copeptin Level in Children with Febrile Seizures. EKB Journal Management System, 2023; 90(2): 3022-3026. doi: 10.21608/ejhm.2023.288377

Diagnostic Utility of Serum Copeptin Level in Children with Febrile Seizures

The Egyptian Journal of Hospital Medicine
Article 156, Volume 90, Issue 2, January 2023, Pages 3022-3026    PDF (296.27 K)
Document Type: Original Article
DOI: 10.21608/ejhm.2023.288377
Authors
Ammar Ali Ammar Abdulhafith* ; Ahmed Galal Siam; Ahmed Abdel Sabour Mohammed; AMR I. Risha
Abstract
Introduction: Febrile seizuresare the most frequent convulsive episode in children, involving 2-5% of those between the ages of six months and five years. Arginine-vasopressin (AVP), a pituitary hormone, has been shown to play a role in response to fever and convulsions, affecting the thermoregulatory system. Copeptin's C-terminal region has been identified as a reliable predictor of AVP production. Objective: The aim of the current study was to assess serum copeptin's diagnostic utility in febrile seizures.
Patients and methods: A case-control study was conducted at Zagazig University’s Emergency Room and Neurology Unit of Children’s Hospital. A total of 46 patients were recruited and were divided into two groups; Febrile seizure group included 23 patients and febrile without seizures group included 23 patients.
Results: There is significant higher copeptin value in febrile seizures group compared to febrile control without seizures group (P<0.05). Copeptin in diagnose seizure patients in febrile patients revealed a sensitivity of 82.6%, a specificity of 78.3% and 80.4% accuracy at a cutoff value >75 pg/ml.
Conclusion: Serum copeptin can tell the difference between a febrile seizure and a febrile without a seizure.Serum copeptin at cut off value >75pg/ml was a good marker for detecting seizures in febrile patients.Serum copeptin performed adequately as a diagnostic tool, highlighting its potential role in the febrile seizure diagnostic algorithm.
 
Keywords
Serum Copeptin; Febrile Seizures; Children; Case control study; Zagazig University
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