Assessment of Serum Level of Chitinase-3-Like-Protein 1 among Psoriatic Patients
El-Gamal, E., Abo Al-Wafa, H., Abd-Alsamee, H., Bazied, M. (2019). Assessment of Serum Level of Chitinase-3-Like-Protein 1 among Psoriatic Patients. EKB Journal Management System, 74(8), 1844-1848. doi: 10.21608/ejhm.2019.28862
Emad Eldin Abdelmoneim El-Gamal; Hany Othman Abo Al-Wafa; Hesham Samir Abd-Alsamee; Marwa Eslam Bazied. "Assessment of Serum Level of Chitinase-3-Like-Protein 1 among Psoriatic Patients". EKB Journal Management System, 74, 8, 2019, 1844-1848. doi: 10.21608/ejhm.2019.28862
El-Gamal, E., Abo Al-Wafa, H., Abd-Alsamee, H., Bazied, M. (2019). 'Assessment of Serum Level of Chitinase-3-Like-Protein 1 among Psoriatic Patients', EKB Journal Management System, 74(8), pp. 1844-1848. doi: 10.21608/ejhm.2019.28862
El-Gamal, E., Abo Al-Wafa, H., Abd-Alsamee, H., Bazied, M. Assessment of Serum Level of Chitinase-3-Like-Protein 1 among Psoriatic Patients. EKB Journal Management System, 2019; 74(8): 1844-1848. doi: 10.21608/ejhm.2019.28862

Assessment of Serum Level of Chitinase-3-Like-Protein 1 among Psoriatic Patients

The Egyptian Journal of Hospital Medicine
Article 22, Volume 74, Issue 8, January 2019, Page 1844-1848  XML PDF (387.62 K)
Document Type: Original Article
DOI: 10.21608/ejhm.2019.28862
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Authors
Emad Eldin Abdelmoneim El-Gamal1; Hany Othman Abo Al-Wafa1; Hesham Samir Abd-Alsamee2; Marwa Eslam Bazied1
1Department of Dermatology, Venerology and Andrology, Faculty of Medicine, Al-Azhar University
2Department of Clinical Pathology, Faculty of Medicine, Al-Azhar University
Abstract
Background: psoriasis is a chronic inflammatory autoimmune skin disorder, with a high relapse rate. The etiology and pathogenesis of psoriasis are still unclear. Many cytokines produced by inflammatory cells give rise to the induction and maintenance of psoriatic plaques. YKL-40 or chitinase 3-like protein1(CHI3L1) may be involved in angiogenesis in psoriasis which has an important role in the pathogenesis of the disease. Objectives: The aim of this study was to study the serum level of YKL-40 in patient with psoriasis in order to assess its possible role in pathogenesis and severity of the disease. Patients and method: this study included 60 psoriatic patients and 30 healthy subjects of matched age and sex, served as a control group. Blood samples were taken from all patients and controls for estimation of serum level of YKL-40 by ELISA. Results: A statistically significant increase in median serum YKL-40 level in psoriatic patients compared with control group. A positive correlation between serum YKL-40 and severity of psoriasis according to PASI score. Conclusion: serum YKL-40 can be used as a new marker for evaluation of disease severity, progression and therapeutic decision in psoriasis.
Keywords
Arachidonic acid; endothelial dysfunction; Epidermal growth factor receptor
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