Topical administration of tacrolimus and systemic corticosteroids in treatment of oral and nasal mucous membrane pemphigoid in a sample of Egyptian population: A randomized control Clinical trial
Hamed, Y., Abd elmoniem, W., Elsayed, M., Essawy, A., Hamed, M., elsherif, R. (2023). Topical administration of tacrolimus and systemic corticosteroids in treatment of oral and nasal mucous membrane pemphigoid in a sample of Egyptian population: A randomized control Clinical trial. EKB Journal Management System, 69(2), 1153-1160. doi: 10.21608/edj.2023.194457.2449
Yasmine Hamed; wesam Abd elmoniem; Mahitab Elsayed; Aya Essawy; Mohamed Hamed; rawda elsherif. "Topical administration of tacrolimus and systemic corticosteroids in treatment of oral and nasal mucous membrane pemphigoid in a sample of Egyptian population: A randomized control Clinical trial". EKB Journal Management System, 69, 2, 2023, 1153-1160. doi: 10.21608/edj.2023.194457.2449
Hamed, Y., Abd elmoniem, W., Elsayed, M., Essawy, A., Hamed, M., elsherif, R. (2023). 'Topical administration of tacrolimus and systemic corticosteroids in treatment of oral and nasal mucous membrane pemphigoid in a sample of Egyptian population: A randomized control Clinical trial', EKB Journal Management System, 69(2), pp. 1153-1160. doi: 10.21608/edj.2023.194457.2449
Hamed, Y., Abd elmoniem, W., Elsayed, M., Essawy, A., Hamed, M., elsherif, R. Topical administration of tacrolimus and systemic corticosteroids in treatment of oral and nasal mucous membrane pemphigoid in a sample of Egyptian population: A randomized control Clinical trial. EKB Journal Management System, 2023; 69(2): 1153-1160. doi: 10.21608/edj.2023.194457.2449

Topical administration of tacrolimus and systemic corticosteroids in treatment of oral and nasal mucous membrane pemphigoid in a sample of Egyptian population: A randomized control Clinical trial

Egyptian Dental Journal
Article 16, Volume 69, Issue 2 - Serial Number 3, April 2023, Page 1153-1160  XML PDF (720.16 K)
Document Type: Original Article
DOI: 10.21608/edj.2023.194457.2449
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Authors
Yasmine Hamedorcid 1; wesam Abd elmoniemorcid 2; Mahitab Elsayedorcid 3; Aya Essawyorcid 3; Mohamed Hamedorcid 4; rawda elsherif email orcid 5
1Lecturer of Oral Medicine and Diagnosis, Department of Oral Medicine, Periodontology and Oral Diagnosis, Faculty of Oral And Dental Surgery, Modern University For Technology & Information
2Professor of Oral Medicine, Department of Oral Medicine and Periodontology, Faculty of Oral and Dental Surgery, Cairo University
3Lecturer of Clinical Pharmacy, Clinical Pharmacy Department, Faculty of Pharmacy, Modern University For Technology & Information
4Associate Professor of Otolaryngology, Faculty of Medicine, Helwan University
5Lecturer of Oral Medicine, Periodontology and Oral Diagnosis, Faculty of Oral and Dental Surgery, Misr University For Science and Technology.
Abstract
Abstract:
Objectives: The study aims to evaluate the effect topical tacrolimus as adjunctive to systemic corticosteroids in treatment of mucous membrane pemphigoid.
Material & Methods: The present study was conducted on 76 patients with severe mucous membrane pemphigoid according to chan et al classification. Patients were allocated (1:1) to a group. Group A (control group) patients treated with 40 mg systemic corticosteroids alone and group B (Study group) patients were treated with 40 mg systemic corticosteroids and topical tacrolimus as adjunctive to corticosteroids. Total ulcers score (site, activity, and pain score) was recorded in both groups on weekly basis till the full recovery of oral, oropharyngeal and nasal lesions.
Results: Both treatment regimen had shown a significant improvement in total ulcer scores with (P<0.001) of the oral and nasal lesion scores from the beginning of the study to its end, but the study group (combination of corticosteroids and tacrolimus) revealed significant decrease (P<0.001) compared to the study (corticosteroid alone) group.
Conclusion: The use of topical tacrolimus as adjunctive to systemic corticosteroids could improve healing and total ulcer score in severe cases of mucous membrane pemphigoid than solo treatment with systemic corticosteroids
Keywords
Mucous membrane pemphigoid; Systemic corticosteroids; Topical tacrolimus; Total ulcers score
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