Topical administration of tacrolimus and systemic corticosteroids in treatment of oral and nasal mucous membrane pemphigoid in a sample of Egyptian population: A randomized control Clinical trial | ||
| Egyptian Dental Journal | ||
| Article 16, Volume 69, Issue 2 - Serial Number 3, April 2023, Pages 1153-1160 PDF (720.16 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/edj.2023.194457.2449 | ||
| Authors | ||
| Yasmine Hamed1; wesam Abd elmoniem2; Mahitab Elsayed3; Aya Essawy3; Mohamed Hamed4; rawda elsherif* 5 | ||
| 1Lecturer of Oral Medicine and Diagnosis, Department of Oral Medicine, Periodontology and Oral Diagnosis, Faculty of Oral And Dental Surgery, Modern University For Technology & Information | ||
| 2Professor of Oral Medicine, Department of Oral Medicine and Periodontology, Faculty of Oral and Dental Surgery, Cairo University | ||
| 3Lecturer of Clinical Pharmacy, Clinical Pharmacy Department, Faculty of Pharmacy, Modern University For Technology & Information | ||
| 4Associate Professor of Otolaryngology, Faculty of Medicine, Helwan University | ||
| 5Lecturer of Oral Medicine, Periodontology and Oral Diagnosis, Faculty of Oral and Dental Surgery, Misr University For Science and Technology. | ||
| Abstract | ||
| Abstract: Objectives: The study aims to evaluate the effect topical tacrolimus as adjunctive to systemic corticosteroids in treatment of mucous membrane pemphigoid. Material & Methods: The present study was conducted on 76 patients with severe mucous membrane pemphigoid according to chan et al classification. Patients were allocated (1:1) to a group. Group A (control group) patients treated with 40 mg systemic corticosteroids alone and group B (Study group) patients were treated with 40 mg systemic corticosteroids and topical tacrolimus as adjunctive to corticosteroids. Total ulcers score (site, activity, and pain score) was recorded in both groups on weekly basis till the full recovery of oral, oropharyngeal and nasal lesions. Results: Both treatment regimen had shown a significant improvement in total ulcer scores with (P<0.001) of the oral and nasal lesion scores from the beginning of the study to its end, but the study group (combination of corticosteroids and tacrolimus) revealed significant decrease (P<0.001) compared to the study (corticosteroid alone) group. Conclusion: The use of topical tacrolimus as adjunctive to systemic corticosteroids could improve healing and total ulcer score in severe cases of mucous membrane pemphigoid than solo treatment with systemic corticosteroids | ||
| Keywords | ||
| Mucous membrane pemphigoid; Systemic corticosteroids; Topical tacrolimus; Total ulcers score | ||
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