Hypervirulent Klebsiella pneumoniae at Benha University Hospitals | ||
| The Egyptian Journal of Hospital Medicine | ||
| Article 314, Volume 90, Issue 2, January 2023, Pages 3592-3597 PDF (497.63 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/ejhm.2023.292752 | ||
| Authors | ||
| Sherin M. Emam; Sawsan Abdelrahman; Amany Abdelaziz Hasan; Marwa S. EL- Melouk | ||
| Abstract | ||
| Background: Hypervirulent Klebsiella pneumoniae (hvKP) is a virulent subtype of K. Pneumoniae. It commonly causes a serious community acquired infections, but it can also cause hospital acquired (nosocomial) infections. Emergence of antimicrobial resistance in hvKP ia a cause of concern. Objective: Phenotypic and molecular characterization and differentiation of classical and hypervirulent klebsiella pneumoniae isolated from Benha University Hospital. Subjects and methods: Klebsiella pneumoniae was isolated bycultivation on Mac-Conkey agar media. Identified phenotypically and subjected to antibiotic sensitivity test. Conventional PCR was performed for detection of RmpA and RmpA2 virulence genes. Results: Eight strains out of 70 (11.4%) K.Pneumoniae were identified as probable hvKP by detection of RmpA2 that was detected in all hvKP while rmpA was detected in 2 out of 8 hvKP isolates. Both cKP and hvKP isolates exhibited high resistance rates for most of the tested antibiotics. Conclusion: Particularly in the presence of antibiotic resistance, HvKP pose a new hazard. Both Rmp A and Rmp A2 virulence genes were strongly associated with hvKP. | ||
| Keywords | ||
| Hypervirulent; Klebsiella pneumoniae; Hypermucoviscosity; String test; Rmp A; Rmp A2 | ||
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