Fetuin-A Ameliorates Lipopolysaccharide-induced Depressive-Like Behavior in Rats Targeting Caspase-1/BDNF/CREB Pathway | ||||
| Bulletin of Egyptian Society for Physiological Sciences | ||||
| Volume 43, Issue 2, April 2023, Page 64-80 PDF (753.03 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/besps.2022.171592.1131 | ||||
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| Authors | ||||
eman basha1; Heba Faheem 2; Hoda Ibrahim 3; Radwa Ismail 4; Mounira Seleem5; Alaa Elkordy6; Haidy Khattab  7
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| 1Medical Physiology Department, Faculty of Medicine, Tanta University , Tanta, Egypt. | ||||
| 2Medical Physiology department, Faculty of Medicine, Tanta University, Tanta, Egypt | ||||
| 3Medical Biochemistry Department, Faculty of Medicine ,Tanta University, Tanta, Egypt | ||||
| 4Anatomy Department, Faculty of Medicine, Tanta University, Tanta, Egypt | ||||
| 5Pharmacology Department, Faculty of Medicine, Tanta University, Tanta, Egypt | ||||
| 6Neuropsychiatry Department, Faculty of Medicine, Tanta University, Tanta, Egypt | ||||
| 7Medical Physiology department, Faculty of Medicine, Tanta university, Tanta, Egypt | ||||
| Abstract | ||||
| Depression is a mental illness that seriously harms human health. Therefore, it is crucial to create antidepressant treatments that are effective and powerful. Fetuin-A is a multifunctional glycoprotein mainly released by hepatocytes; it has a complex role in inflammatory processes. We aimed to examine the effect of fetuin-A on lipopolysaccharide-induced depressive like behavior in rats. Forty male albino rats were randomly categorized into four groups; Group I: Control group: (saline + vehicle) for 10 days, Group II: Control treated by fetuin-A group: fetuin-A (100 mg/kg/day) for 10 days, Group III: Depression group: 0.5 mg/kg lipopolysaccharide for 10 days, Group IV: Depression treated with fetuin-A group: Lipopolysaccharide (0.5 mg/kg) for 10 days followed by fetuin-A (100 mg/kg) for 10 days. Behavioral impairments were evaluated. Brain levels of malondialdehyde (MDA) and glutathione peroxidase (GPX) were estimated. The levels of tumor necrosis factor-alpha (TNF-α), interleukin (IL) IL-6, and brain-derived neurotrophic factor (BDNF), were measured by ELISA. AMPA glutamate receptors (AMPARs GluA1&2), caspase-1 and cAMP response element-binding protein (CREB) mRNA expression by real-time PCR were done. Histopathological assessment of hippocampus was done. Our results revealed that fetuin-A effectively ameliorated LPS-induced behavioral tests impairment through increasing BDNF and CREB. Additionally, fetuin-A treatment caused a decrease in the levels of MDA, TNF-α and IL-6 together with concomitant elevation of GPX and upregulation of caspase-1 and AMPAR GluA1&2 expression. We concluded that fetuin-A ameliorates depression-like behaviors of rats by controlling the Caspase-1/BDNF/CREB Pathway signaling pathway, which may serve as a new target for treatment of depression. | ||||
| Keywords | ||||
| Fetuin-A; BDNF; depression; caspase-1 | ||||
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