Potential protective Effect of Sycamore fruits and leaves extracts against diclofenac-induced liver toxicity in male rats | ||||
| مجلة دراسات وبحوث التربية النوعية | ||||
| Volume 9, Issue 2 - Serial Number 20, April 2023, Page 623-645 PDF (883.05 K) | ||||
| Document Type: المقالة الأصلية | ||||
| DOI: 10.21608/jsezu.2023.294394 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
| Zeinab Abdellateaf Hassan; Yosra H. Darwish; Amira M. Elmoslemany | ||||
| Nutrition and Food Science Department, Faculty of Home Economics, Al-Azhar University, Tanta | ||||
| Abstract | ||||
| Diclofenac (DIC), also known as Voltaren, is a member of the group of drugs that don't contain steroids that fight inflammation. Liver toxicity is one of the primary concerns regarding this medication, which is one of the substances that come from phenylacetic acid. This study examined the impact of a ficus sycomorus leaf and fruit ethanolic extract on oxidative stress and hepatotoxicity caused by diclofenac in rats. There were forty-two male albino rats, each weighing about 150 grammes (±10 g). They were divided into seven equal groups. The first group of six rats was given a basic diet as a negative control. At the conclusion of the trial, the second group (36 rats) was given a single dose of DIC (150 mg/kg b.w.) given through the abdomen. Six subgroups were created from it: As a positive control (+v), Group 1 was given only a basal diet. Group 2 was given silymarin (100 mg/kg b.w., orally) along with a basal diet. For 28 days, groups 3 and 4 were given a basal diet and an ethanolic sycamore fruit extract (200 and 400 mg/kg b.w.), in that order. A basal diet and an oral ethanolic extract of sycamore leaves (200 and 400 mg/kg b.w.) were administered to groups 5 and 6, respectively. Blood samples were collected for biochemical analysis, and biological data were computed at the conclusion of the experiment. Malondialdehyde (MDA), antioxidant markers, and histological analysis were also performed on liver tissues. According to the findings, the diclofenac group decreased serum liver GPX, SOD, and CAT while increasing liver weight, serum liver enzymes, liver MDA, and liver NO. When you look at the (+ve) control group, every group that received fruit and leaf extracts demonstrated improvement in every prior metric. To sum up, eating the ficus sycomorus leaf ethanolic extract and fruits can lessen the negative effects of the toxicant diclofenac. | ||||
| Keywords | ||||
| diclofenac; ficus sycomorus; silymarin; hepatotoxicity | ||||
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