The Impact of Topically Applied 1% Phenytoin Gel on Treatment of Periodontitis Stage II and III Grade A | ||
| Al-Azhar Assiut Dental Journal | ||
| Article 5, Volume 6, Issue 1, April 2023, Pages 45-54 PDF (1.7 M) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/aadj.2023.296418 | ||
| Authors | ||
| Alaa El-Dein Mohamed Salatein* 1; Mohamed Fouad Edrees1; Gamal Mohamed Soltan Zayed2; Ibrahim Hammad Ibrahim2; Ahmed Mohamed Bakry3 | ||
| 1Department of Oral medicine, Periodontology, Diagnosis and Oral radiology, Faculty of Dental Medicine, (Assiut, boys), Al-Azhar University, Egypt. | ||
| 2Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy (Assiut, girls), Al-Azhar University, Egypt | ||
| 3Department of Oral and Maxillofacial Radiology, Faculty of dentistry, Minia University, Egypt | ||
| Abstract | ||
| Aim: The aim of the present study was to evaluate the efficacy of topically applied 1% phenytoin as an adjunctive treatment in Stage II or III, Grade A periodontitis patients. Subjects and Methods: This study was designed as a split-mouth randomized controlled clinical, carried out on 20 patients of both sexes (12 female and 8 male), aged from (33-55) years with mean age (43.25± 6.64) with stage II or III, grade A periodontitis. Patients’ sides were classified randomly into the following groups: Group < /div> I: included 20 sides with Stage II or III, Grade A periodontitis patients treated by scaling and root planing alone. Group II: included 20 sides with Stage II or III, Grade A periodontitis patients treated by scaling and root planing combined with 1% phenytoin gel. All patients were evaluated clinically at; baseline, 1, 3 and 6 months using plaque index (PI), gingival index (GI), probing pocket depth (PPD), clinical attachment level (CAL) and radiographically by evaluation of the marginal bone level (MBL). Results: Phenytoin group: showed reduction in PPD and CAL, as well as significant gain in MBL than group I at 6 months after treatment Conclusion: The adjunctive use of 1% PHT in-situ gel exhibited an attractive effect on probing pocket depth reduction clinical attachment gain in non-surgical treatment of stage II and III grade A periodontitis. Phenytoin 1% in-situ gel seemed to have an osteogenic efficacy through the reported marginal bone gain in treatment of stage II and III grade A periodontitis patients. | ||
| Keywords | ||
| Periodontitis Stage II and III Grade A; scaling and root planing; 1% Phenytoin Gel | ||
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