Pre-Contrast Hemogram-Derived Indices as Predictors for Contrast-Induced Acute Kidney Injury After Percutaneous Coronary Intervention
Al-Nahal, A., Mahmoud, M., Amin, M., Naguib, M., Sakla, N. (2023). Pre-Contrast Hemogram-Derived Indices as Predictors for Contrast-Induced Acute Kidney Injury After Percutaneous Coronary Intervention. EKB Journal Management System, 91(1), 4546-4553. doi: 10.21608/ejhm.2023.296761
Al-Sayed Ahmed Hassan Al-Nahal; Medhat Ibrahim Mahmoud; Mohamed Ibrahim Amin; Mostafa Abd-Elwahab Naguib; Niveen Shafeek Shokry Sakla. "Pre-Contrast Hemogram-Derived Indices as Predictors for Contrast-Induced Acute Kidney Injury After Percutaneous Coronary Intervention". EKB Journal Management System, 91, 1, 2023, 4546-4553. doi: 10.21608/ejhm.2023.296761
Al-Nahal, A., Mahmoud, M., Amin, M., Naguib, M., Sakla, N. (2023). 'Pre-Contrast Hemogram-Derived Indices as Predictors for Contrast-Induced Acute Kidney Injury After Percutaneous Coronary Intervention', EKB Journal Management System, 91(1), pp. 4546-4553. doi: 10.21608/ejhm.2023.296761
Al-Nahal, A., Mahmoud, M., Amin, M., Naguib, M., Sakla, N. Pre-Contrast Hemogram-Derived Indices as Predictors for Contrast-Induced Acute Kidney Injury After Percutaneous Coronary Intervention. EKB Journal Management System, 2023; 91(1): 4546-4553. doi: 10.21608/ejhm.2023.296761

Pre-Contrast Hemogram-Derived Indices as Predictors for Contrast-Induced Acute Kidney Injury After Percutaneous Coronary Intervention

The Egyptian Journal of Hospital Medicine
Article 121, Volume 91, Issue 1, April 2023, Pages 4546-4553    PDF (602.73 K)
Document Type: Original Article
DOI: 10.21608/ejhm.2023.296761
Authors
Al-Sayed Ahmed Hassan Al-Nahal; Medhat Ibrahim Mahmoud; Mohamed Ibrahim Amin; Mostafa Abd-Elwahab Naguib; Niveen Shafeek Shokry Sakla
Abstract
Background: Percutaneous coronary intervention (PCI) may be complicated by contrast-induced acute kidney injury (CI-AKI). The current study aimed to evaluate the pre-contrast hemogram-derived indices as early predictors for CI-AKI after PCI. Methods: A case-control study involved 54 patients who underwent PCI, divided into Group I (27 patients with no CI-AKI), and Group II (27 patients with CI-AKI). After the history taking, examination and routine laboratory investigations, the pre-contrast hemogram-derived indices were calculated; neutrophil / lymphocyte ratio (NLR), platelet / lymphocyte ratio (PLR), neutrophil / platelet ratio (NPR), monocyte / lymphocyte ratio (MLR), eosinophil / lymphocyte ratio (ELR), and systemic immune-inflammation (SII) index (platelet count × (neutrophil count / lymphocyte count).
Results: There were significantly higher pre-contrast leucocytes, neutrophils, NLR (p˂0.001) (HS), MLR, PLR, NPR, ELR, and SII in group II than in group I (p˂0.05). The ROC analysis showed a significant predictive value for pre-contrast NLR (92.8% sensitivity & 51.3% specificity), NPR (42.8% & 86.4%), and SII (53.5% & 81.1%), MLR (85.7% & 43.2%), and ELR (50% & 78.3%). The odds ratios (OR) for pre-contrast hemogram-induced indices as predictors for CI-AKI, with confidence interval (CI) 95% were as follows; NLR OR (2.12), CI (0.71-6.31); PLR OR (2.11), CI (0.71-6.26); SII OR (2.96), CI (0.96-9.11); MLR OR (2.89), CI (0.95-8.72); ELR OR (3.4), CI (1.11-10.4); NPR OR (2.5), CI (0.82-7.53); RDW OR (2.12), CI (0.71-6.31). Conclusion: Hemogram-derived indices including pre-contrast SII, NLR, NPR, and MLR may be useful early predictors for CI-AKI after PCI.
 
Keywords
CI-AKI; NLR; NPR; SII; MLR; PLR; ELR
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