Evaluation of the clinicopathological significance of E-Cadherin and Ki 67 immuno-expression in triple negative breast cancer | ||||
| Egyptian Journal of Cancer and Biomedical Research | ||||
| Volume 7, Issue 1, March 2023, Page 55-67 PDF (8.02 MB) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/jcbr.2023.181487.1287 | ||||
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| Authors | ||||
Eman Basiouny Esmail   1; Mohammed Ali El-rashidy2; Heba Abd El-hai Mashhour3; Hend Salah Abo-Safia3
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| 1Faculty of Medicine, Tanta University, Tanta, Egypt. Pathology resident in Tanta Cancer Centre, Tanta, Egypt. | ||||
| 2Pathology department- Faculty of Medicine –Tanta University | ||||
| 3Pathology Department, Faculty of Medicine, Tanta University, Tanta, Egypt. | ||||
| Abstract | ||||
| Background: Breast cancer is one of the most diverse and well-known diseases. It has various molecular subtypes, clinical behaviors, therapeutic responses, and patient outcomes. The absence of hormonal expression (ER&PR) and the lack of excessive human epidermal growth factor receptor 2 expression are the two characteristics that are often used to identify triple-negative breast cancer (HER2). E-Cadherin is a cell adhesion molecule that inhibits metastasis, invasion, and cell growth. A non-histone nuclear protein called Ki 67 is connected to tissue and cellular proliferation. Aim of the work: to evaluate the pattern of expression of E-cadherin and Ki 67 in the studied triple-negative breast cancer cases and to find their correlation with various clinicopathological parameters. Materials & Methods: This study was carried out on 60 cases of triple-negative breast cancer. Immunohistochemical staining using E-cadherin and Ki 67 antibodies was done for all cases to evaluate their pattern of expression. Results: There was a significant statistical negative relation between E-cadherin expression in TNBC and pleomorphic lobular subtype and axillary lymph node metastasis. Also, there was a significant statistical relation between high Ki 67 index (P value < 0.05) and high-grade histological types of TNBC cases, age groups and cases from lower inner quadrant. Conclusions: Decreased E-cadherin expression is related to positive nodal metastasis. High tumour grade was substantially correlated with high levels of Ki-67 expression. | ||||
| Keywords | ||||
| E-Cadherin; Ki 67; Triple Negative Breast Cancer; non-histone nuclear protein; cell adhesion molecule | ||||
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