Synthesis, In Vitro Biological Investigation, and In Silico Analysis of Pyrazole-Based Derivatives as Multi-target Agents | ||
| Egyptian Journal of Chemistry | ||
| Article 44, Volume 66, Issue 6, June 2023, Pages 441-455 PDF (1.05 M) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/ejchem.2023.205639.7863 | ||
| Authors | ||
| Ashraf S. Hassan* 1; Wael Mahmoud Aboulthana2 | ||
| 1Organometallic and Organometalloid Chemistry Department, National Research Centre, Dokki 12622, Cairo, Egypt | ||
| 2Biochemistry Department, Biotechnology Research Institute, National Research Centre, Dokki 12622, Cairo, Egypt | ||
| Abstract | ||
| The diseases-related complications and causes are threaded. Accordingly, the preparation of one drug with multiple targets is very pressing. In this context, the three series of pyrazole-based derivatives 7a-c, 9a-c, and 11a-c were designed and synthesized by using 5-amino-pyrazoles 3a-c as starting materials. The structures of various products 7a-c, 9a-c, and 11a-c were characterized by using various devices (elemental analysis and spectral tools). The biological activities of pyrazole-based products 7a-c, 9a-c, and 11a-c were estimated as antioxidant, anti-diabetic, anti-Alzheimer, and anti-arthritic. The estimation results showed that the two products 7c and 11a displayed powerful biological activities. In silico analysis (physicochemical, drug-likeness, and toxicity properties) of the two products 7c and 11a was performed. This research could be valuable for the exploration of one drug with multiple targets. | ||
| Keywords | ||
| Pyrazole-based products; Pharmacophore; Physicochemical properties; Anti-diabetic activity; Diseases-related complications | ||
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