Antitumor Potential and Possible Targets of Phenothiazine Derivatives: A Recent Review | ||
| Egyptian Journal of Chemistry | ||
| Volume 66, Issue 13, December 2023, Pages 1001-1014 PDF (1.89 M) | ||
| Document Type: Review Articles | ||
| DOI: 10.21608/ejchem.2023.199175.7715 | ||
| Authors | ||
| Mona O Sarhan* 1; Nosaiba Attia Fayadh2; Radwan Elhaggar3; Wafaa Zaghary4 | ||
| 1Labelled Compounds Department, Hot Lab Center, Egyptian Atomic Energy Authority | ||
| 2Pharmaceutical Chemistry department Faculty of pharmacy Helwan University Cairo Egypt | ||
| 3Helwan University | ||
| 41Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Helwan University, P.O. Box 11795, Cairo, Egypt | ||
| Abstract | ||
| The unique chemical characteristics of the phenothiazine ring system have been a major driving force for the development of various phenothiazine-based compounds with a huge spectrum of industrial and biological significance. Literature is ever continuously growing discussing the different roles and synthetic routes of phenothiazines. A huge body of novel and repurposed phenothiazines have been reported to have antitumor action. Unfortunately, only few reports discuss the proper mechanism of such action. In this review, a comprehensive overview of the identified targets and/or mechanism of action of recently reported antitumor phenothiazine derivatives are reviewed. | ||
| Keywords | ||
| Phenothiazine; Antitumor; Molecular targets; Hybridization; Repurposing | ||
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