Efficacy of Silodosin versus Sildosin plus Tadalafil as medical expulsive therapy for lower ureteric stones: A prospective randomized placebo controlled study
El Hadj Sidi, A., Diab, T., El-Shazly, A., El-Dakhakhni, A., Abdel-Azim, A. (2023). Efficacy of Silodosin versus Sildosin plus Tadalafil as medical expulsive therapy for lower ureteric stones: A prospective randomized placebo controlled study. EKB Journal Management System, 40(1), 254-263. doi: 10.21608/bmfj.2023.201688.1786
Abdellahi Mohameden El Hadj Sidi; Tamer Diab; Ali Mohamed El-Shazly; Amr Salah El-Dakhakhni; Abdallah Fathy Abdel-Azim. "Efficacy of Silodosin versus Sildosin plus Tadalafil as medical expulsive therapy for lower ureteric stones: A prospective randomized placebo controlled study". EKB Journal Management System, 40, 1, 2023, 254-263. doi: 10.21608/bmfj.2023.201688.1786
El Hadj Sidi, A., Diab, T., El-Shazly, A., El-Dakhakhni, A., Abdel-Azim, A. (2023). 'Efficacy of Silodosin versus Sildosin plus Tadalafil as medical expulsive therapy for lower ureteric stones: A prospective randomized placebo controlled study', EKB Journal Management System, 40(1), pp. 254-263. doi: 10.21608/bmfj.2023.201688.1786
El Hadj Sidi, A., Diab, T., El-Shazly, A., El-Dakhakhni, A., Abdel-Azim, A. Efficacy of Silodosin versus Sildosin plus Tadalafil as medical expulsive therapy for lower ureteric stones: A prospective randomized placebo controlled study. EKB Journal Management System, 2023; 40(1): 254-263. doi: 10.21608/bmfj.2023.201688.1786

Efficacy of Silodosin versus Sildosin plus Tadalafil as medical expulsive therapy for lower ureteric stones: A prospective randomized placebo controlled study

Benha Medical Journal
Article 23, Volume 40, Issue 1, May and June 2023, Page 254-263  XML PDF (350.69 K)
Document Type: Original Article
DOI: 10.21608/bmfj.2023.201688.1786
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Authors
Abdellahi Mohameden El Hadj Sidi email 1; Tamer Diab2; Ali Mohamed El-Shazly3; Amr Salah El-Dakhakhni3; Abdallah Fathy Abdel-Azim3
1Department of urology Faculty of Medicine , Benha University
2Lecturer of Urology Faculty of Medicine, Benha University
3Professor of Urology Faculty of Medicine , Benha University
Abstract
Purpose : To compare the efficacy of silodosin , silodosin plus tadalafil and placebo as a medical expulsive therapy (MET) for distal ureteral calculi. Subjects & methods: This prospective randomized clinical trial was conducted on 120 renal colic patients with distal ureteric stones (5-10mm) over a period of 6 months (1st February , 2022 to 1st August , 2022 ) . The patients were randomly divided into three equal groups . Patients included in A received Placebo treatment once daily , in group B received Silodosin 8 mg once daily, while patients in group C received Silodosin 8 mg in combination with tadalafil 10mg once daily .Therapy was given for a maximum of 4 weeks . Stone free rate, time to stone expulsion, dose and duration of nonsteroidal anti-inflammatory drugs (NSAIDs), hospital visits due to pain, and adverse effects induced by the drugs were recorded. Results: The expulsion rate significantly differed between the studied groups (P < 0.001). Regarding expulsion time, there was a significant difference between the studied groups. The number of pain episodes showed an overall significant difference between the studied groups. The number of pain episodes showed an overall significant difference between the studied groups. Side effects significantly differed between the studied groups (P < 0.001). The predictors were Sildosin use, combined drug use, and stone size. Conclusion : Medical expulsive therapy for distal ureteric stone using Tadalafil in combination with silodosin is safe , well tolerated , and more effective than silodosin alone .
Keywords
ureteral stones; tadalafil; silodosin
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