Toxoplasma gondii seropositivity among Egyptian children with haematological malignancies
ElBlihy, A., Alhusseiny, S., Abd Elmabood, S., El-Beshbishi, S. (2023). Toxoplasma gondii seropositivity among Egyptian children with haematological malignancies. EKB Journal Management System, 16(1), 57-63. doi: 10.21608/puj.2023.199269.1204
Ayat ElBlihy; Samar Alhusseiny; Suzy Abd Elmabood; Samar El-Beshbishi. "Toxoplasma gondii seropositivity among Egyptian children with haematological malignancies". EKB Journal Management System, 16, 1, 2023, 57-63. doi: 10.21608/puj.2023.199269.1204
ElBlihy, A., Alhusseiny, S., Abd Elmabood, S., El-Beshbishi, S. (2023). 'Toxoplasma gondii seropositivity among Egyptian children with haematological malignancies', EKB Journal Management System, 16(1), pp. 57-63. doi: 10.21608/puj.2023.199269.1204
ElBlihy, A., Alhusseiny, S., Abd Elmabood, S., El-Beshbishi, S. Toxoplasma gondii seropositivity among Egyptian children with haematological malignancies. EKB Journal Management System, 2023; 16(1): 57-63. doi: 10.21608/puj.2023.199269.1204

Toxoplasma gondii seropositivity among Egyptian children with haematological malignancies

Parasitologists United Journal
Article 6, Volume 16, Issue 1, April 2023, Pages 57-63    PDF (405.51 K)
Document Type: Original Article
DOI: 10.21608/puj.2023.199269.1204
Authors
Ayat ElBlihy* 1; Samar Alhusseiny1; Suzy Abd Elmabood2; Samar El-Beshbishi1
1Departments of Medical Parasitology , Faculty of Medicine, Mansoura University, Mansoura 35516- Egypt
2Departments of Pediatrics Haematology and Oncology Unit , Faculty of Medicine, Mansoura University, Mansoura 35516- Egypt
Abstract
Background: Toxoplasmosis is caused by T. gondii leading to severe complications in immunocompromised
patients.
Objective: The present case-control study aims at determining T. gondii seroprevalence among children
with haematological malignancies.
Subjects and Methods: A total of 320 children were included (160 children with different types of
haematological malignancies, and 160 matched controls). Anti-T. gondii IgM and IgG antibodies were
assessed in sera from all participants using ELISA. Data included socio-demographic characteristics,
predisposing factors for toxoplasmosis, and recorded type of haematological malignancy.
Results: All the recruited children were seronegative for anti-T. gondii IgM antibodies. The seroprevalence
of anti-T. gondii IgG antibody in cancer patients and controls was 62.5% and 20%, respectively. Besides,
children with haematological malignancies had significantly higher levels of anti-T. gondii IgG antibody,
with the highest antibody seroprevalence rate and titer detected in children with lymphoblastic lymphoma
(LL) and Burkitt's lymphoma (BL), respectively. Age ≥ 8 years, female gender, rural residence, low socioeconomic
standard, blood transfusion, and toxoplasmosis in other family members were recorded as
significant risk factors for toxoplasmosis.
Conclusion: The high prevalence of anti-T. gondii IgG antibody in children with haematological
malignancies necessitates routine screening for toxoplasmosis, to avoid development of severe and
disseminated disease.
Keywords
children; Egypt; ELISA; leukaemia; lymphoma; risk factors; seroprevalence; T. gondii
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