Impact of the follicular fluid Coenzyme Q10 level in women undergoing intracytoplasmic sperm injection (ICSI) on the pregnancy rate | ||
| SVU-International Journal of Medical Sciences | ||
| Article 26, Volume 6, Issue 2, July 2023, Pages 279-290 PDF (248.28 K) | ||
| Document Type: Original research articles | ||
| DOI: 10.21608/svuijm.2023.207121.1578 | ||
| Authors | ||
| Mahmoud S Iwes1; Mohamed Atef ELZarka* 1; Hanan M. Fayed2; Ahmed Hashim Abdellah1; Mohammad A.M. Ahmed1 | ||
| 1Obstetrics and Gynecology Department, Faculty of Medicine, South Valley University, Qena, Egypt. | ||
| 2Clinical and Chemical Pathology Department, Faculty of Medicine, South Valley University , Qena, Egypt. | ||
| Abstract | ||
| Background: The most crucial problem with in vitro fertilization (IVF) cycles is still oocyte quality. The women age and the condition of their ovarian reserve are the primary determinants of oocyte quality. Objectives: to assess the effects of intracytoplasmic sperm injection (ICSI) on the result of pregnancies and the coenzyme Q10 (CoQ10) value in follicular fluid (FF) in the women who had the procedure. Patients and methods: this cohort investigation was conducted on 81 infertile patients (age between 20-42 years, both normal or poor responders’ patients and patients with unexplained infertility) who underwent ICSI cycles. Results: patients were divided into two groups: the pregnant group (n= 32) and the non-pregnant group (n= 49).There was a statistically insignificant difference in antral follicle count (AFC), number of retrieved oocytes, number of embryos, number of metaphase II (MII) oocytes, and maturation index between pregnant and non-pregnant females. CoQ10 level in FF was substantially greater in pregnant than non-pregnant females. Conclusion: FF CoQ10 levels were positively correlated with eventual embryo quality and rates of conception. Our findings might be in favour of CoQ10 supplementation in women undergoing IVF for enhancement of the ovum and embryo quality. | ||
| Keywords | ||
| Coenzyme Q10; Follicular fluid; Embryo; Pregnancy rate; Assisted reproductive technique | ||
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