APELIN INDUCED MODULATION OF UTERINE CONTRACTILITY IN ADULT ALBINO RATS AND ITS POSSIBLE MECHANISM/S OF ACTION
Asalah, A., mansour, S., Attia, K., Mahdi, S. (2020). APELIN INDUCED MODULATION OF UTERINE CONTRACTILITY IN ADULT ALBINO RATS AND ITS POSSIBLE MECHANISM/S OF ACTION. EKB Journal Management System, 26(1), 174-185. doi: 10.21608/zumj.2019.11148.1157
Ali Khalil Asalah; sherif wagih mansour; Kamelia Ibrahim Attia; Somya El-sayed Mahdi. "APELIN INDUCED MODULATION OF UTERINE CONTRACTILITY IN ADULT ALBINO RATS AND ITS POSSIBLE MECHANISM/S OF ACTION". EKB Journal Management System, 26, 1, 2020, 174-185. doi: 10.21608/zumj.2019.11148.1157
Asalah, A., mansour, S., Attia, K., Mahdi, S. (2020). 'APELIN INDUCED MODULATION OF UTERINE CONTRACTILITY IN ADULT ALBINO RATS AND ITS POSSIBLE MECHANISM/S OF ACTION', EKB Journal Management System, 26(1), pp. 174-185. doi: 10.21608/zumj.2019.11148.1157
Asalah, A., mansour, S., Attia, K., Mahdi, S. APELIN INDUCED MODULATION OF UTERINE CONTRACTILITY IN ADULT ALBINO RATS AND ITS POSSIBLE MECHANISM/S OF ACTION. EKB Journal Management System, 2020; 26(1): 174-185. doi: 10.21608/zumj.2019.11148.1157

APELIN INDUCED MODULATION OF UTERINE CONTRACTILITY IN ADULT ALBINO RATS AND ITS POSSIBLE MECHANISM/S OF ACTION

Zagazig University Medical Journal
Article 21, Volume 26, Issue 1, January and February 2020, Pages 174-185    PDF (1.62 M)
Document Type: Original Article
DOI: 10.21608/zumj.2019.11148.1157
Authors
Ali Khalil Asalah1; sherif wagih mansour2; Kamelia Ibrahim Attia3; Somya El-sayed Mahdi* 4
1department of physiology , faculty of medicine , Zagazig university
2physiology department , faculty of medicine zagazig university
3department of physiology . faculty of medicine , zagazig univeristy
4Physiology department faculty of medicine Zagazig university
Abstract
ABSTRACT
Background: Apelin is an endogenous ligand for the G protein-coupled receptor APJ , The expression of both apelin and APJ has been detected in a variety of tissues including heart, ,ovary , placenta and uterus. It has a relaxant effect on smooth muscles of the stomach and blood vessels. However , its effect and mechanism of action on the smooth muscle of the uterus are still controversy

Aim of the study : This study was designed to demonstrate the in vitro effects and mechanism of action of apelin on rat uterine reactivity.

Material and Methods: 60 adult albino rats (48 females and 12 males). Female rats were randomly divided into non- pregnant, pregnant (day 6 and day 19 ) and 1st day postpartum groups. The effects of apelin (1,10 and 100 nmol /L) on spontaneous reactivity of isolated uterine strips were studied. Also, apelin (100 nmol/L) in the presence of L-NAME , apamin and Glibenclamide was investigated.
Results: Apelin exerted a significant dose dependent reduction in frequency and amplitude of spontaneous uterine contraction. This reduction was significantly more potent on day 6 than that in both non pregnant and pregnant rats on day 19. Also , it was significantly and nearly completely abolished in the presence of L-NAME, but it was significantly and partially decreased in the presence of (Apamin) and (Glibenclamide).
Conclusion: Apelin has a potent utero-relaxant effect which is greater in early pregnancy compared with late pregnancy. Thus Apelin may be a promising tocolytic drug.
Keywords
Apelin; uterine contractility; Pregnancy
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