Voltammetric Determination of Rebamipide in the presence of its degradant in bulk, pharmaceutical preparation, and biological fluids
Abdallah, O., Mohamed, T., Hendawy, H., Elomda, H. (2023). Voltammetric Determination of Rebamipide in the presence of its degradant in bulk, pharmaceutical preparation, and biological fluids. EKB Journal Management System, 3(2), 133-140. doi: 10.21608/aijpms.2023.163295.1171
Ola M Abdallah; Taghreed A. Mohamed; Hassan AM Hendawy; Hager Reda Elomda. "Voltammetric Determination of Rebamipide in the presence of its degradant in bulk, pharmaceutical preparation, and biological fluids". EKB Journal Management System, 3, 2, 2023, 133-140. doi: 10.21608/aijpms.2023.163295.1171
Abdallah, O., Mohamed, T., Hendawy, H., Elomda, H. (2023). 'Voltammetric Determination of Rebamipide in the presence of its degradant in bulk, pharmaceutical preparation, and biological fluids', EKB Journal Management System, 3(2), pp. 133-140. doi: 10.21608/aijpms.2023.163295.1171
Abdallah, O., Mohamed, T., Hendawy, H., Elomda, H. Voltammetric Determination of Rebamipide in the presence of its degradant in bulk, pharmaceutical preparation, and biological fluids. EKB Journal Management System, 2023; 3(2): 133-140. doi: 10.21608/aijpms.2023.163295.1171

Voltammetric Determination of Rebamipide in the presence of its degradant in bulk, pharmaceutical preparation, and biological fluids

Azhar International Journal of Pharmaceutical and Medical Sciences
Volume 3, Issue 2, June 2023, Page 133-140  XML PDF (483.35 K)
Document Type: Original research articles
DOI: 10.21608/aijpms.2023.163295.1171
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Authors
Ola M Abdallahorcid 1; Taghreed A. Mohamed2; Hassan AM Hendawyorcid 2; Hager Reda Elomda email orcid 2
1Pharmaceutical Analytical Chemistry Department, Facutly of Pharmacy (Girls), Al-Azhar University, Cairo, Egypt
2Pharmaceutical Chemistry Department, Egyptian Drug Authority, Giza, Egypt.
Abstract
In this work, we develop, optimize and validate an electrochemical method for determining Rebamipide (REBA) using anodic differential pulse voltammetry (A-DPV) for the first time. The choice of the proper anode was determined through a comparative study between electrodes, and we found the proper one is the carbon nano-tubes that are modified with the nano form of zinc oxide electrode (ZnONP/CNT/ME). The degradant pathway of the Rebamipide was illustrated by FTIR. For the REBA quantification, we have used a 0.04M B-R buffer electrolyte solution (PH = 11.0) using the ZnONP/CNT/ME. The peak showed linearity in the range of (0.09-12.37 µg/mL), limit of detection was 0.028 µg/mL and the limit of quantification was 0.086 µg/mL. Our proposed method proved a good validation profile regarding accuracy, precision, and reproducibility in comparison to the official method. Conclusively, this work suggests the usage of a rapid, sensitive, cheap, and, most importantly, environmentally friendly protocol to determine the REBA either in the presence of its degradant, in its pharmaceutical form, or in human serum.
Keywords
Rebamipide; Differential Pulse voltammetry; Multiwall-carbon-nanotube; Mucosta®; Biological fluids
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